Detrusor smooth muscle in rats with alloxan-induced diabetes

The Journal of Urology
B Uvelius

Abstract

Following five weeks of alloxan-induced diabetes, female rats were killed and the urinary bladder was used either for organ bath experiments, collagen determination or electron microscopy. Mean bladder weight increased from 70 +/- 3 (SE, n = 8) for controls to 131 +/- 7 mg. (n = 9) for the diabetic rats. Collagen concentration decreased from 104 +/- 5 (n = 8) to 69 +/- 4 (n = 9) micrograms/mg. but due to the weight gain total bladder collagen increased from 7.4 +/- 0.6 to 8.9 +/- 0.3 mg. Electron microscopy indicated an increase in mean cross-sectional area of the detrusor smooth muscle cells from 8.1 +/- 0.5 (n = 132) to 19 +/- 0.9 (n = 144) mu 2. Despite these changes the bladders from diabetic animals and the controls had similar characteristics with regard to nerve mediated frequency-response relations, atropine resistance, responses to alpha-agonists and high-K+ solution. No functional neurogenic lesion and no impairment of smooth muscle cell contractility could thus be detected, and it is proposed that the bladder hypertrophy in the diabetic animals is due to a physiological adaptation to the four-fold increase in urinary production.

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Citations

Nov 1, 1992·The Journal of Urology·P A LonghurstR M Levin
Mar 21, 2008·Neurourology and Urodynamics·Guiming LiuFirouz Daneshgari
Jul 16, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Vivian Alves PereiraFrancisco J B Sampaio
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
May 1, 1990·The Journal of Urology·W D SteersW C de Groat
Oct 1, 1993·The Journal of Urology·B EikaP A Longhurst
Jan 1, 1994·Neurourology and Urodynamics·W D Steers
Jun 17, 2004·American Journal of Physiology. Renal Physiology·Xiaoling SuRobert S Moreland
Dec 21, 2010·BJU International·Marcelo Abidu-FigueiredoFrancisco J B Sampaio
Mar 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guiming Liu, Firouz Daneshgari
Oct 1, 2008·Acta Cirúrgica Brasileira·Antonio Antunes RodriguesAntonio Carlos Pereira Martins
Jul 23, 2004·Physiological Reviews·Karl-Erik Andersson, Anders Arner
Jul 24, 2014·Acta Cirúrgica Brasileira·Ana Beatriz Gomes de Souza PegorareHaylton Jorge Suaid
Dec 1, 1996·The American Journal of Physiology·S GuptaI Saenz De Tejada

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