Deuterated Drugs

Journal of Psychosocial Nursing and Mental Health Services
Robert H Howland

Abstract

Many drugs are carbon-based, and carbon-hydrogen bonding is particularly relevant for understanding important properties of drug molecules. Deuteration refers to the selective replacement of protium hydrogen isotope atoms in small-molecule drugs with deuterium hydrogen isotope atoms. Deuteration of a drug is most likely to affect pharmacokinetic properties, such as metabolism, rather than its pharmacodynamic effects. For this reason, the metabolism of certain drugs may be favorably influenced when deuterium is substituted for protium, resulting in improved safety, tolerability, or efficacy. Examples of deuterated drugs that have been evaluated in clinical studies include paroxetine, tetrabenazine, and dextromethorphan.

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Citations

Jan 24, 2019·Pharmaceutics·Laurent EttouatiHatem Fessi
Jan 18, 2018·Clinical Schizophrenia & Related Psychoses·Michael A CummingsStephen M Stahl
Jul 13, 2017·Expert Opinion on Pharmacotherapy·Lauren C Seeberger, Robert A Hauser
Nov 8, 2016·Expert Opinion on Pharmacotherapy·Joseph Jankovic
Nov 12, 2020·Expert Review of Neurotherapeutics·Benjamin J Dorfman, Joohi Jimenez-Shahed
May 27, 2020·Pharmacology & Therapeutics·Jessa KochKhashayar Dashtipour
Jul 17, 2021·ACS Medicinal Chemistry Letters·Hao XiaoHank F Kung

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