Deuteration of water enables self-organization of phospholipid-based reverse micelles

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Jeannine MilhaudEdith Hantz

Abstract

Phospholipid-based reverse micelles are composed of branched cylinders. Their branching points are known to attract themselves and to slide along branches. The rate of this sliding is governed by the lifetime of H(D)-bonded water bridges between phospholipid molecules. This lifetime is increased when the water is deuterated. On condition that the water contains at least 40 D atoms%, water/dipalmitoylphosphatidylcholine (DPPC)/deuterated pyridine reverse micelles with the composition 1.1:1:250 (v/v) have been shown to self-organize into a liquid crystal in the 310-316 K temperature range. The mechanism of this self-organization is unraveled by following the FTIR and (1)H NMR spectra of more concentrated micelles upon heating. During the preparation of micelles, pyridine-(D(+))H(+) ions are formed. They give rise to hydron transfers, under the influence of the DPPC electric charges, evidenced by two broad FTIR absorptions above (BB1) and below (BB2) the nu(C-O) stretch. These hydron transfers occur along strong (D(+))H(+) bonds of pyridinium ions with pyridine (BB1) and DPPC C=O groups (BB2). The proton transfers at the interface of micelles, relayed in the continuous pyridine medium, create a tenuous link between separated micel...Continue Reading

References

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Citations

Sep 21, 2011·The Journal of Physical Chemistry. a·Nancy E LevingerThomas Elsaesser

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