PMID: 6017980Feb 24, 1967Paper

Deuterium oxide: direct action on sympathetic ganglia isolated in culture

Science
M R MURRAY, H H BENITEZ

Abstract

Immature ganglia from chicks and rodents were maintained as organized, developing cultures for 2 months or more, during which time they were continuously exposed to deuterium oxide in their medium. Observations of the living cell communities with the light microscope indicated that deuteration within viable limits (up to 25 percent) accelerates and increases the growth of sympathetic neurons and favors their repeated subdivision as a very large size is attained, thus inducing them to recapitulate cyclically the early stages of neurogenesis. Living deuterated cells appear more opaque and heteromerous than control neurons; furthermore, electron micrographs reveal an unusual abundance of granular and fibrillar elements in the nuclei of both neurons and supporting cells. Sheaves of complexly organized fibrillar components appear in the neuronal perikaryon; and ribosomes, Golgi elements, and microtubules are conspicuously numerous. Both fine structure and function of these ganglia therefore appear to have been modified directly by action of the deuterium isotope.

References

Mar 11, 1966·Science·J J Katz, H L Crespi
Jan 1, 1965·International Review of Cytology·E FlaumenhaftJ J Katz
Mar 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·P BACHNERD RITTENBERG

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Citations

Jan 1, 1967·Zeitschrift für Zellforschung und mikroskopische Anatomie·R Morales, D Duncan
Nov 1, 1976·Journal of Neurobiology·U De BoniD R Crapper
Jul 7, 1970·Biochimica Et Biophysica Acta·C K Akers, D F Parsons
Dec 1, 1973·Journal of Pharmaceutical Sciences·R G Rahwan, J L Borowitz
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·J H ChamleyG Burnstock

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