Developing a Core Outcome Set for Cesarean Delivery Maternal Infectious Morbidity Outcomes

American Journal of Perinatology
Kristin E Briscoe, David M Haas

Abstract

This study aimed to develop a core outcome set of primary outcomes for studies involving cesarean deliveries with infectious morbidity outcomes. Authors reported primary outcomes from 11 Cochrane systematic reviews (SRs), 12 other SRs, and 327 randomized controlled trials (RCTs). These outcomes were condensed into 20 primary outcome groups. Next, a modified Delphi technique was used to gain consensus on key outcomes. Authors from included SRs were sent a questionnaire consisting of a free response and multiple-choice questions. These data were used to propose a set of core outcomes. The most frequent outcomes in RCTs were composite "infectious outcomes" (24%) with the second most common being endometritis (12%). The most common reported SR outcomes were wound infection (21%) and endometritis (16%). For the Delphi survey free response portion, wound infection (88%) and endometritis (79%) were the most commonly endorsed outcomes. Chosen list outcomes were maternal mortality (83%), wound infection (83%), wound complications (86%), and postpartum endometritis (80%). The proposed final core outcome set for cesarean trials was endometritis (primary outcome), maternal mortality, wound infection, wound complications, febrile morbidity,...Continue Reading

Citations

Apr 27, 2020·The Cochrane Database of Systematic Reviews·David M HaasSavannah Kimball
Sep 21, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Victoria Hodgetts-MortonRachel K Morris
Aug 21, 2020·BMC Pregnancy and Childbirth·Maarten D H VinkEric J E van der Hijden
Feb 11, 2021·Journal of Midwifery & Women's Health·Valerie SlavinJenny Gamble
Oct 11, 2021·BMC Pregnancy and Childbirth·Marie ÖsterbergMaria Jonsson

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