Developing a New Generation of Antimicrobial and Bioactive Dental Resins

Journal of Dental Research
Lei ChengH H K Xu

Abstract

Dental caries is prevalent, and secondary caries causes restoration failures. This article reviews recent studies on developing a new generation of bioactive resins with anticaries properties. Extensive effects were made to develop new antimicrobial composites, bonding agents, and other resins containing quaternary ammonium methacrylates to suppress plaque buildup and bacterial acid production. The effects of alkyl chain length and charge density and the antimicrobial mechanisms for chlorhexidine, nano-silver, quaternary ammonium methacrylates, and protein-repellent agents were discussed. Synergistic effects of contact-killing and protein-repellent properties were shown to yield the greatest biofilm-inhibition effects. The combination of antimicrobial, protein-repellent, and calcium phosphate nanoparticle remineralization was suggested to provide maximal anticaries effects. In addition, for use orally, cytotoxicity and biocompatibility were important considerations for the new bioactive materials. Furthermore, rather than kill all bacteria, it would be more desirable to modulate the oral biofilm compositions via bioactive resins to suppress cariogenic/pathogenic species and promote benign species. For widespread clinical use of...Continue Reading

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Citations

Nov 23, 2018·Drug Delivery and Translational Research·Suping WangHockin H K Xu
Nov 2, 2018·Dental Materials Journal·Abdul Samad Khan, Mariam Raza Syed
Jan 15, 2020·Dental Materials Journal·Satoshi ImazatoHaruaki Kitagawa
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May 12, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Haruaki KitagawaSatoshi Imazato
May 18, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Weidan LuoLei Cheng
Sep 19, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Zhongni ZhangCui Huang
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Aug 21, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Hao LiLei Cheng

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