Developing Combined HIV Vaccine Strategies for a Functional Cure

Vaccines
Alessandra Noto, Lydie Trautmann

Abstract

Increasing numbers of HIV-infected individuals have access to potent antiretroviral drugs that control viral replication and decrease the risk of transmission. However, there is no cure for HIV and new strategies have to be developed to reach an eradication of the virus or a natural control of viral replication in the absence of drugs (functional cure). Therapeutic vaccines against HIV have been evaluated in many trials over the last 20 years and important knowledge has been gained from these trials. However, the major obstacle to HIV eradication is the persistence of latent proviral reservoirs. Different molecules are currently tested in ART-treated subjects to reactivate these latent reservoirs. Such anti-latency agents should be combined with a vaccination regimen in order to control or eradicate reactivated latently-infected cells. New in vitro assays should also be developed to assess the success of tested therapeutic vaccines by measuring the immune-mediated killing of replication-competent HIV reservoir cells. This review provides an overview of the current strategies to combine HIV vaccines with anti-latency agents that could act as adjuvant on the vaccine-induced immune response as well as new tools to assess the effic...Continue Reading

References

Oct 31, 1996·The New England Journal of Medicine·J A KovacsH C Lane
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·T W ChunA S Fauci
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J Marks-KonczalikY Tagaya
Oct 12, 2000·Nature·E S RosenbergB D Walker
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·T W ChunA S Fauci
Aug 2, 2001·Nature Medicine·M Altfeld, B D Walker
Jul 23, 2002·Journal of Virology·Yael D KorinJerome A Zack
Oct 24, 2002·Blood·Yvonne M MuellerPeter D Katsikis
Apr 2, 2003·Nature Reviews. Immunology·Kimberly S Schluns, Leo Lefrançois
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Thérèse NugeyreNicole Israël
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher A KlebanoffNicholas P Restifo
Apr 6, 2005·The Journal of Infectious Diseases·Matthew C StrainJoseph K Wong
Jun 7, 2005·The Journal of Clinical Investigation·Irini SeretiH Clifford Lane
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stéphanie BeqNicole Israël
Aug 19, 2006·Nature Medicine·Lydie TrautmannRafick-Pierre Sekaly
Sep 7, 2006·The Journal of Experimental Medicine·Constantinos PetrovasRichard A Koup
Jan 26, 2007·The Journal of General Virology·Annette R RodriguezKrishna K Murthy
Nov 17, 2007·The EMBO Journal·Mudit Tyagi, Jonathan Karn
Jun 7, 2008·Nature Medicine·Victor AppayDavid A Price
Sep 12, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Victor AppayMario Roederer
Dec 17, 2008·Nature·Vijayakumar VeluRama Rao Amara
Dec 18, 2008·Nature Immunology·Karl-Johan Malmberg, Hans-Gustaf Ljunggren
Feb 14, 2009·The New England Journal of Medicine·Gero HütterEckhard Thiel
Apr 18, 2009·Current Opinion in HIV and AIDS·Michael R Betts, Alexandre Harari
Apr 22, 2009·Blood·Irini SeretiUNKNOWN ACTG 5214 Study Team
Jun 23, 2009·Nature Medicine·Nicolas ChomontRafick-Pierre Sékaly

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
histone acetylation

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.