Developing community-based urine sampling methods to deploy biomarker technology for the assessment of dietary exposure.

Public Health Nutrition
A J LloydJ Draper

Abstract

Obtaining objective, dietary exposure information from individuals is challenging because of the complexity of food consumption patterns and the limitations of self-reporting tools (e.g., FFQ and diet diaries). This hinders research efforts to associate intakes of specific foods or eating patterns with population health outcomes. Dietary exposure can be assessed by the measurement of food-derived chemicals in urine samples. We aimed to develop methodologies for urine collection that minimised impact on the day-to-day activities of participants but also yielded samples that were data-rich in terms of targeted biomarker measurements. Urine collection methodologies were developed within home settings. Different cohorts of free-living volunteers. Home collection of urine samples using vacuum transfer technology was deemed highly acceptable by volunteers. Statistical analysis of both metabolome and selected dietary exposure biomarkers in spot urine collected and stored using this method showed that they were compositionally similar to urine collected using a standard method with immediate sample freezing. Even without chemical preservatives, samples can be stored under different temperature regimes without any significant impact on ...Continue Reading

References

May 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marie-Paule GonthierAugustin Scalbert
May 20, 2003·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·C Frobisher, S M Maxwell
Nov 1, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Martin B LeeMichael Lever
Apr 3, 2008·International Journal of Epidemiology·Paul ElliottUNKNOWN UK Biobank
Feb 24, 2009·European Journal of Clinical Nutrition·A J AdamsonUNKNOWN Newcastle 85+ Study Core Team
Mar 13, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Matti MarklundAfaf Kamal-Eldin
Aug 19, 2010·Molecular & Cellular Proteomics : MCP·Lennart MartensEric W Deutsch
Nov 6, 2010·Genes & Nutrition·Linda PennJohn C Mathers
Nov 1, 2011·Metabolomics : Official Journal of the Metabolomic Society·Gaëlle FavéJohn C Mathers
Oct 12, 2012·Nature Biotechnology·Matthew C ChambersParag Mallick
Jan 14, 2016·Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society·Sherri O StuverLisa Fredman
Feb 26, 2016·Journal of Agricultural and Food Chemistry·Isabel Garcia-PerezGary Frost
Dec 17, 2016·Metabolomics : Official Journal of the Metabolomic Society·Markus RotterRui Wang-Sattler
Dec 22, 2016·Analytica Chimica Acta·Jérôme LaparreGaud Dervilly-Pinel
May 3, 2019·Metabolomics : Official Journal of the Metabolomic Society·A J LloydJ Draper

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