Developing DCE-CT to quantify intra-tumor heterogeneity in breast tumors with differing angiogenic phenotype

IEEE Transactions on Medical Imaging
Minsong CaoKeith M Stantz

Abstract

The objective of this study is to evaluate the ability of dynamic contrast enhanced computed tomography (DCE-CT) to assess intratumor physiological heterogeneity in tumors with different angiogenic phenotypes. DCE-CT imaging was performed on athymic nude mice bearing xenograft wild type (MCF-7(neo)) and VEGF-transfected (MCF-7(VEGF)) tumors by using a clinical multislice CT, and compared to skeletal muscle. Parametrical maps of tumor physiology--perfusion (F), permeability-surface area (PS), fractional intravascular plasma (f(p)), and interstitial space (f(is))--were obtained by fitting the time-dependent contrast-enhanced curves to a two-compartmental kinetic model for each voxel (0.3 x 0.3 x 0.75 mm(3)). Mean physiological measurements were compared with (positron emission tomography (PET) imaging, and the spatial distribution of tumor vasculature was compared with histology. No statistically significant difference was found in mean physiological values of F, PS, and f(p) in MCF-7(neo) and muscle, while f(is) of MCF-7(neo) was a factor of two higher ( p < 0.04). MCF-7(neo) tumors also showed a radial heterogeneity with significant higher physiological values in periphery than those in middle and core regions ( p < 0.01 for al...Continue Reading

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Citations

Oct 20, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Keith M StantzKathy D Miller
May 5, 2011·Journal of Biomedicine & Biotechnology·Xiangyu Yang, Michael V Knopp
Jul 28, 2010·IEEE Transactions on Medical Imaging·Andrij AbramyukNasreddin Abolmaali
Sep 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shawn StapletonDavid A Jaffray
Oct 11, 2016·Medical Image Analysis·Ruud Jg van SlounMassimo Mischi
Dec 9, 2020·Technology in Cancer Research & Treatment·Sai LiYupeng Hong
Sep 7, 2018·Biomedical Physics & Engineering Express·L Ayala-Domínguez, M E Brandan

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