PMID: 9550138Apr 29, 1998Paper

Developing grasshopper neurons show variable levels of guanylyl cyclase activity on arrival at their targets

The Journal of Comparative Neurology
E E Ball, J W Truman

Abstract

The ability of certain grasshopper neurons to respond to exogenously applied donors of nitric oxide (NO) by producing cyclic GMP (cGMP) depends on their developmental state. ODQ, a selective blocker of NO-sensitive guanylyl cyclase, blocks cGMP production at 10(-5) M, thus confirming the nature of the response. Experiments in which the distal axon is separated from its proximal stump before application of an NO donor show that guanylyl cyclase is distributed uniformly throughout the neuron. In the locust abdomen, where segments are formed sequentially, the pattern of guanylyl cyclase up-regulation is predictable and sequential from anterior to posterior. There are two patterns of innervation by cGMP-expressing motor neurons. In the first, typified by muscle 187, an innervating neuron begins to be NO responsive on arrival at its muscle and continues to be so over most of the remainder of embryonic development, including the formation of motor end plates. In the second, typified by a neuron innervating muscle 191, the neuron extends well along the muscle, apparently laying down a number of sites of contact with it, before it becomes NO responsive. In both patterns, however, NO responsiveness marks the neuron's transition from gro...Continue Reading

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Citations

Mar 11, 2004·The European Journal of Neuroscience·Kevin R Trimm, Vincent Rehder
Oct 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sabine Knipp, Gerd Bicker
May 11, 1999·Journal of Neurobiology·S Van Wagenen, V Rehder
Sep 25, 2001·Archives of Insect Biochemistry and Physiology·G Bicker
Jun 11, 1999·Journal of Neurobiology·B Wildemann, G Bicker
Jun 21, 2006·Cellular and Molecular Neurobiology·Ricardo M Zayas, Barry A Trimmer
Nov 30, 2007·Developmental Neurobiology·Michael Stern, Gerd Bicker
May 21, 2003·Parasitology Research·Margaretha K S GustafssonSergei O Movsessian
Apr 16, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gerd Bicker
Sep 18, 2002·Brain Research. Developmental Brain Research·Claudia Seidel, Gerd Bicker

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