Developing injectable immunoglobulins to treat cognitive impairment in Alzheimer's disease

Expert Opinion on Biological Therapy
Michael Steinitz

Abstract

Alzheimer's disease is a devastating disorder, clinically characterized by a comprehensive cognitive decline. The novel strategy of anti-amyloid-beta immunotherapy has been suggested following encouraging results obtained in murine models of Alzheimer's disease, in non-human primates, and in small-scale clinical trials. To examine the choice between active or passive anti-amyloid-beta immunization and the choice of the molecule to which the immune machinery should be targeted, which are central issues in future immune therapy of Alzheimer's disease. Research into the new area of Alzheimer's disease immune therapy is primarily based on in vivo and in vitro studies of murine models of Alzheimer's disease. The studies are hence limited to defined genetic deficiencies. In humans, infusion of anti-amyloid-beta antibodies is considered a safer approach than active anti-amyloid-beta vaccination. Alzheimer's-disease-protective anti-amyloid-beta monoclonal antibodies should target specific epitopes within the amyloid beta(1 42) peptide, avoiding possibly harmful binding to the ubiquitous normal amyloid precursor protein. Since Alzheimer's disease immunotherapy requires repeated infusion of antibodies over a prolonged period of time, Alz...Continue Reading

References

Nov 1, 1981·Journal of Neuropathology and Experimental Neurology·J M PowersB J Hall
Jan 1, 1994·Progress in Brain Research·R D Terry
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·J F PodusloC T Berg
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·B SolomonT Katzav
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·B SolomonE Hanan-Aharon
Nov 5, 1997·Annals of the New York Academy of Sciences·D G MunozV Hachinski
Mar 7, 2000·Lancet·F C Breedveld
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Jul 20, 2000·Journal of the American Academy of Dermatology·R K ListerM H Rustin
Jun 21, 2001·Annals of Neurology·B T HymanR Mayeux
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·R B DeMattosD M Holtzman
Sep 12, 2001·Medicine·J R BergerW F Maragos
Apr 26, 2002·Toxicology·Roly Foulkes
Jul 12, 2002·Journal of Neuroscience Research·Neelima B Chauhan, George J Siegel
Oct 3, 2002·Nature Reviews. Neuroscience·Dale Schenk
Oct 31, 2002·Nature Neuroscience·Martin Citron
Jan 2, 2003·Nature Reviews. Drug Discovery·Ole Henrik Brekke, Inger Sandlie
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Frédérique BardTed Yednock
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rena LiYong Shen
Jun 9, 2004·Protein and Peptide Letters·Dominic M Walsh, Dennis J Selkoe
Jun 16, 2004·Alzheimer Disease and Associated Disorders·Sam GandyEvan T Keller
Sep 21, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·R C DodelW H Oertel
Sep 29, 2004·Neuron·Dominic M Walsh, Dennis J Selkoe
Dec 8, 2004·Experimental Gerontology·Michael J RowanRoger Anwyl

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Citations

Aug 12, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Colin K Combs
Apr 7, 2009·Expert Opinion on Biological Therapy·Gregory A Jicha

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