Developing nucleic acid-based electrical detection systems

Microbial Cell Factories
Magdalena Gabig-Ciminska

Abstract

Development of nucleic acid-based detection systems is the main focus of many research groups and high technology companies. The enormous work done in this field is particularly due to the broad versatility and variety of these sensing devices. From optical to electrical systems, from label-dependent to label-free approaches, from single to multi-analyte and array formats, this wide range of possibilities makes the research field very diversified and competitive. New challenges and requirements for an ideal detector suitable for nucleic acid analysis include high sensitivity and high specificity protocol that can be completed in a relatively short time offering at the same time low detection limit. Moreover, systems that can be miniaturized and automated present a significant advantage over conventional technology, especially if detection is needed in the field. Electrical system technology for nucleic acid-based detection is an enabling mode for making miniaturized to micro- and nanometer scale bio-monitoring devices via the fusion of modern micro- and nanofabrication technology and molecular biotechnology. The electrical biosensors that rely on the conversion of the Watson-Crick base-pair recognition event into a useful elect...Continue Reading

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Citations

Sep 12, 2008·Applied Microbiology and Biotechnology·Daniel PiochBritta Jürgen
Sep 10, 2013·Biosensors & Bioelectronics·Muhammad Ali Syed
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Dec 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ali OthmanSilvana Andreescu
Mar 14, 2019·Chemical Reviews·Siyuan S Wang, Andrew D Ellington

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Methods Mentioned

BETA
chips
nucleic acid chips
Biosensors
chip
PCR
nucleic acid sensing
biochips
nucleic acid detection
biosensing
nucleic

Software Mentioned

BLAST

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