Developing Open-Source Models for the US Health System: Practical Experiences and Challenges to Date with the Open-Source Value Project

PharmacoEconomics
Jeroen P JansenMark T Linthicum

Abstract

The Innovation and Value Initiative started the Open-Source Value Project with the aim to improve the credibility and relevance of model-based value assessment in the context of the US healthcare environment. As a core activity of the Open-Source Value Project, the Innovation and Value Initiative develops and provides access to flexible open-source economic models that are developed iteratively based on public feedback and input. In this article, we describe our experience to date with the development of two currently released, Open-Source Value Project models, one in rheumatoid arthritis and one in epidermal growth factor receptor-positive non-small-cell lung cancer. We developed both Open-Source Value Project models using the statistical programming language R instead of spreadsheet software (i.e., Excel), which allows the models to capture multiple model structures, model sequential treatment with individual patient simulations, and improve integration with formal evidence synthesis. By developing the models in R, we were also able to use version control systems to manage changes to the source code, which is needed for iterative and collaborative model development. Similarly, Open-Source Value Project models are freely avail...Continue Reading

References

Jul 1, 1990·Medical Decision Making : an International Journal of the Society for Medical Decision Making·W C Black
Apr 22, 2008·Statistics in Medicine·Marta FioccoHans C van Houwelingen
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Garry R BartonElisabeth A L Fenwick
Dec 24, 2008·BMC Health Services Research·Mireille M GoetghebeurDonna Rindress
Sep 20, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·David M EddyUNKNOWN ISPOR-SMDM Modeling Good Research Practices Task Force
Jan 24, 2014·International Journal of Technology Assessment in Health Care·Giovanni RadaelliMichele Tringali
Jun 10, 2016·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Claire WilliamsDaniel F Mackay
Dec 9, 2016·PharmacoEconomics·William C N DunlopRon L Akehurst
Jan 7, 2017·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Hawre JalalM G Myriam Hunink
Feb 27, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Louis P GarrisonPeter J Neumann
Feb 27, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Darius N LakdawallaPatricia M Danzon
Feb 27, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Richard J WillkeScott D Ramsey
Mar 28, 2018·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Eline M KrijkampPetros Pechlivanoglou
Apr 4, 2018·Annals of Internal Medicine·Joshua T CohenJohn B Wong

❮ Previous
Next ❯

Citations

Aug 29, 2020·The Patient·Mark T LinthicumJennifer L Bright
Sep 12, 2020·Wellcome Open Research·Robert Smith, Paul Schneider
Oct 24, 2019·PharmacoEconomics·Paul Tappenden, J Jaime Caro
Mar 30, 2021·Journal of Managed Care & Specialty Pharmacy·Jason ShafrinPeter Neumann

❮ Previous
Next ❯

Software Mentioned

hesim
Git
heemod
Visual Basic for Applications
Travis
OSVP
BCEA
MCDA
Excel
Visual Basic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.