PMID: 22583409May 16, 2012Paper

Developing phytoestrogens for breast cancer prevention

Anti-cancer Agents in Medicinal Chemistry
Mandy M LiuJeffrey Wang

Abstract

Breast cancer is one of the most common types of cancer in women, and is the second leading cause of cancer-related deaths in the United States. Chemoprevention using phytoestrogens (PEs) for breast cancer may be a valid strategy. PEs are phytochemicals with estrogen-like structures and can be classified into four types: isoflavones, lignans, stilbenes and coumestans. They are widely distributed in diet and herbs and have shown anti-cancer activity via mechanisms including estrogen receptor modulation, aromatase inhibition, and anti-angiogenesis. Genistein, daidzein and resveratrol are some of the most studied PE examples. Quality control in product manufacturing and clinical study design is a critical issue in developing them as clinically effective chemopreventive agents for breast cancer.

Citations

Aug 2, 2013·BMC Complementary and Alternative Medicine·Mariana S CamargoEliana A Varanda
Sep 21, 2013·Expert Opinion on Investigational Drugs·Zhijun WangYing Huang
Jan 23, 2016·Enzyme Research·Edwin D Lephart
May 23, 2015·Nutrition and Cancer·Kyung-A Hwang, Kyung-Chul Choi
Mar 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lenka VarinskaPeter Kruzliak
May 6, 2015·Food & Function·Ashley S WilkinsonSarah J Roberts-Thomson
Jun 8, 2018·Phytotherapy Research : PTR·Harini Anandhi SenthilkumarEdward J Kennelly
Apr 4, 2017·The British Journal of Nutrition·Chen PengCai-Xia Zhang
Dec 5, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Marius Trésor Wego KamgaingSylvie Lea Wansi Ngnokam
Mar 7, 2014·Central European Journal of Public Health·Miroslava Bilecová-RabajdováMária Mareková
Jan 6, 2021·Menopause : the Journal of the North American Menopause Society·Xiao-Li FengCai-Xia Zhang

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