Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite

Journal of Tropical Medicine
Tommaso C BulfoneMatthew R Lewin

Abstract

The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge. Small molecule therapeutics (SMTs) have been proposed as potential prereferral treatments for snakebite to help address this gap. Herein, we discuss the characteristics, potential uses, and development of SMTs as potential treatments for snakebite envenomation. We focus on SMTs that are secretory phospholipase A2 (sPLA2) inhibitors with brief exploration of other potential drug targets on venom molecules.

References

Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·C L OwnbyI I Kaiser
May 16, 1988·The Medical Journal of Australia·B CurrieJ Oakley
Jul 7, 1998·Toxicology and Applied Pharmacology·M Bazin-RedureauJ M Scherrmann
Oct 29, 1998·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezF Chaves
Nov 22, 2000·Biochimie·S BraudA Wisner
Nov 6, 2003·Biochemical Pharmacology·Yamileth Angulo, Bruno Lomonte
Nov 14, 2003·Toxicology and Applied Pharmacology·Teresa EscalanteJosé María Gutiérrez
Oct 7, 2004·Biochemical and Biophysical Research Communications·Wen-Jeng WangTur-Fu Huang
Jan 22, 2005·Emergency Medicine Journal : EMJ·N SharmaS Varma
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·R Manjunatha Kini
Jun 18, 2005·Journal of Molecular Biology·Mário T MurakamiRaghuvir K Arni
Oct 27, 2005·Current Medicinal Chemistry·Andreimar M SoaresPaulo S Pereira
Dec 16, 2006·Journal of Biochemical and Biophysical Methods·Joseph A Price
Jan 2, 2007·Toxicon : Official Journal of the International Society on Toxinology·J-M HowesG D Laing
Jul 31, 2010·Toxicon : Official Journal of the International Society on Toxinology·R Manjunatha Kini, Robin Doley
Aug 13, 2010·Journal of Infection and Public Health·A AnilIan D Simpson
Nov 26, 2010·British Journal of Pharmacology·J P HughesK L Philpott
Mar 31, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Apr 13, 2011·Acta Physiologica·K Näreoja, J Näsman
Feb 24, 2012·Bioinformation·Ramar Perumal SamyVincent Tk Chow
Sep 25, 2012·Toxicon : Official Journal of the International Society on Toxinology·Francis S Markland, Stephen Swenson
Jan 9, 2013·Expert Opinion on Therapeutic Patents·Victoria Magrioti, George Kokotos
Oct 17, 2013·PLoS Neglected Tropical Diseases·Udaya K RanawakaH Janaka de Silva
Oct 31, 2013·BioMed Research International·B M A CarvalhoD P Marchi-Salvador
Nov 20, 2013·JAMA : the Journal of the American Medical Association·Stephen J NichollsUNKNOWN VISTA-16 Investigators
Nov 28, 2013·PloS One·Sakthivel VaiyapuriE Gail Hutchinson
Mar 4, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·D Z HungM Y Liau
Mar 4, 2014·PLoS Neglected Tropical Diseases·Dirk F van HeldenGeoffrey K Isbister
Jul 12, 2012·ACS Medicinal Chemistry Letters·Fabián Villalta-RomeroEnrique Pérez-Payá
Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nicholas R CasewellRobert A Harrison
Dec 3, 2014·Journal of Proteomics·André ZelanisChristopher M Overall
Mar 24, 2015·Journal of Medicinal Chemistry·Dennis A SmithLi Di
Jul 2, 2015·Toxicon : Official Journal of the International Society on Toxinology·Joseph A Price
Aug 5, 2015·Toxicon : Official Journal of the International Society on Toxinology·Andreas H LaustsenJosé María Gutiérrez
Aug 11, 2015·British Journal of Clinical Pharmacology·H Asita de SilvaH Janaka de Silva
Nov 7, 2015·Toxicon : Official Journal of the International Society on Toxinology·Juan J Calvete, Bruno Lomonte

❮ Previous
Next ❯

Citations

Nov 8, 2018·Toxins·Erick Bermúdez-MéndezAndreas Hougaard Laustsen
May 8, 2020·Science Translational Medicine·Laura-Oana AlbulescuNicholas R Casewell
Mar 29, 2021·Trends in Pharmacological Sciences·Rachel H ClareNicholas R Casewell
Jul 20, 2021·Toxicon : Official Journal of the International Society on Toxinology·Ashis K Mukherjee, Stephen P Mackessy
Aug 26, 2021·Toxicon: X·Muhammad HamzaAbdulrazaq G Habib
Sep 28, 2021·Journal of Medicinal Chemistry·Upasana PuzariAshis K Mukherjee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.