Developing vitamin D dietary guidelines and the lack of 25-hydroxyvitamin D assay standardization: The ever-present past

The Journal of Steroid Biochemistry and Molecular Biology
C T SemposG D Carter

Abstract

Unstandardized laboratory measurement of 25-hydroxyvitamin D (25(OH)D) confounds efforts to develop clinical and public health vitamin D guidelines. The Vitamin D Standardization Program (VDSP), an international collaborative effort, was founded in 2010 to correct this problem. Nearly all published vitamin D research is based on unstandardized laboratory 25(OH)D measurements. While it is impossible to standardize all old data, it may be possible to identify a small subset of prior studies critical to guidelines development. Once identified it may be possible to calibrate their 25(OH)D values to the NIST and Ghent University reference measurement procedures using VDSP methods thereby permitting future guidelines to be based on standardized results. We simulated the calibration of a small set of ten clinical trials of vitamin D supplementation on achieved 25(OH)D under minimal sun exposure. These studies were selected because they played a prominent role in setting the 2010 vitamin D dietary reference intakes (DRI). Using random-effects meta-regression analysis, Vitamin D External Quality Assessment (DEQAS) data on assay bias was used to simulate the potential bias due to the lack of assay standardization by calibrating the achie...Continue Reading

Citations

Apr 13, 2019·Journal of Midwifery & Women's Health·Mary McNamara, Kelly D Rosenberger
May 7, 2016·Nature Reviews. Cardiology·Stefan PilzWinfried März
Jan 11, 2020·Hormones : International Journal of Endocrinology and Metabolism·Konstantinos MakrisEtienne Cavalier
Feb 6, 2017·Endocrine·Roger Bouillon
Dec 8, 2017·International Journal of Molecular Sciences·Agnieszka GerkowiczGrażyna Chodorowska
Oct 12, 2017·American Journal of Epidemiology·Anne Marie Z JukicPamela L Lutsey
Nov 11, 2017·Public Health Nutrition·Mona S Calvo, Christel J Lamberg-Allardt
Dec 2, 2017·Nutrients·Christine L TaylorPatsy M Brannon
Mar 23, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E JakabH P Bhattoa
Nov 17, 2020·Expert Review of Proteomics·Yuqin WangWilliam J Griffiths
Mar 14, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Konstantinos MakrisAnnemieke C Heijboer
May 21, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T ChevalleyR Rizzoli
Aug 28, 2021·International Journal of Molecular Sciences·Massimo De MartinisSebastiano Gangemi
Aug 31, 2021·International Journal of Endocrinology·Nino TurashviliElene Giorgadze

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