Development and antifungal evaluation of a food-grade U-type microemulsion

Journal of Applied Microbiology
Hui ZhangX Zheng

Abstract

Food-grade microemulsions have been of increasing interest to researchers as potential delivery systems for bioactive compounds. However, food-grade microemulsions are difficult to formulate and no microemulsion has been documented for antifungal purpose. The physicochemical characterization of a food-grade glycerol monolaurate (GML)/ethanol (EtOH)/Tween 80/potassium sorbate (PS)/water microemulsion system and the antifungal activities against Aspergillus niger and Penicillium italicum have been studied in this paper. The influence of EtOH and PS on oil solubilization capability was clearly reflected in the phase behaviour of U-type microemulsion systems. One dilution-stable formulation ME (GML/EtOH/Tween 80/PS/water = 3 : 3 : 3.5 : 10.5 : 16) was selected. After 4 days of incubation, ME showed 80%A. niger growth inhibition at 0.2% and 72%P. italicum growth inhibition at 0.1%, respectively, and a delay of conidiation of 2 days compared with the control. In the antifungal activities of the microemulsion, GML and PS made major contributions with similar antifungal activities at a GML/PS weight ratio of 1: 3.5. Food-grade dilution-stable microemulsions prepared with GML as oil phase for antifungal purpose are feasible and solubili...Continue Reading

References

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Citations

May 4, 2010·Applied Microbiology and Biotechnology·Hui ZhangLirong Shen
Jul 9, 2013·International Journal of Pharmaceutics·Ibrahim S I Al-AdhamPhillip J Collier
Jun 29, 2010·International Journal of Pharmaceutics·Hui ZhangXiaodong Zheng

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