Development and application of a microfabricated multimodal neural catheter for neuroscience

Biomedical Microdevices
Chunyan LiJed A Hartings

Abstract

We present a microfabricated neural catheter for real-time continuous monitoring of multiple physiological, biochemical and electrophysiological variables that are critical to the diagnosis and treatment of evolving brain injury. The first generation neural catheter was realized by polyimide-based micromachining and a spiral rolling packaging method. The mechanical design and electrical operation of the microsensors were optimized and tailored for multimodal monitoring in rat brain such that the potential thermal, chemical and electrical crosstalk among the microsensors as well as errors from micro-environmental fluctuations are minimized. In vitro cytotoxicity analyses suggest that the developed neural catheters are minimally toxic to rat cortical neuronal cultures. In addition, in vivo histopathology results showed neither acute nor chronic inflammation for 7 days post implantation. The performance of the neural catheter was assessed in an in vivo needle prick model as a translational replica of a "mini" traumatic brain injury. It successfully monitored the expected transient brain oxygen, temperature, regional cerebral blood flow, and DC potential changes during the passage of spreading depolarization waves. We envisage that...Continue Reading

References

Nov 19, 2002·Neuroscience Letters·Frank RichterHans-Georg Schaible
Jun 6, 2003·Journal of Neurophysiology·Frank RichterHans-Georg Schaible
Oct 21, 2006·Biosensors & Bioelectronics·Chunyan LiChong H Ahn
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May 17, 2008·Biomedical Microdevices·Chunyan LiChong H Ahn
May 23, 2008·Annals of Neurology·Christian DohmenUNKNOWN Co-Operative Study of Brain Injury Depolarisations (COSBID)
Jul 25, 2009·Biosensors & Bioelectronics·Chunyan LiRaj K Narayan
May 4, 2010·Annals of Neurology·Bert BoscheUNKNOWN Members of the Cooperative Study of Brain Injury Depolarizations (COSBID)
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Oct 25, 2011·PloS One·Jiangang DuSotiris C Masmanidis
Nov 8, 2011·Lancet Neurology·Jed A HartingsUNKNOWN Co-Operative Study on Brain Injury Depolarisations
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Oct 25, 2008·Sensors·Mohamad HajjHassanSam Musallam

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Citations

Sep 7, 2016·Frontiers in Neuroscience·Kanokwan LimnusonChunyan Li
Sep 2, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chunyan LiJed A Hartings
Mar 20, 2019·Critical Care Medicine·Chunyan LiRaj K Narayan
Mar 7, 2021·International Journal of Molecular Sciences·Baptiste BalançaAnne-Claire Lukaszewicz

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