Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors

Annual Review of Analytical Chemistry
Hsien-Wei Yeh, Hui-Wang Ai

Abstract

Although fluorescent reporters and biosensors have become indispensable tools in biological and biomedical fields, fluorescence measurements require external excitation light, thereby limiting their use in thick tissues and live animals. Bioluminescent reporters and biosensors may potentially overcome this hurdle because they use enzyme-catalyzed exothermic biochemical reactions to generate excited-state emitters. This review first introduces the development of bioluminescent reporters, and next, their applications in sensing biological changes in vitro and in vivo as biosensors. Lastly, we discuss chemiluminescent sensors that produce photons in the absence of luciferases. This review aims to explore fundamentals and experimental insights and to emphasize the yet-to-be-reached potential of next-generation luminescent reporters and biosensors.

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W W LorenzM J Cormier
Jul 1, 1989·Journal of Bioluminescence and Chemiluminescence·K V WoodW D McElroy
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E M ThompsonF I Tsuji
Jan 1, 1986·Methods in Enzymology·J R de WetM DeLuca
Feb 1, 1987·Molecular and Cellular Biology·J R de WetS Subramani
Apr 9, 1969·Journal of the American Chemical Society·E H WhiteH H Seliger
Feb 8, 2000·Luminescence : the Journal of Biological and Chemical Luminescence·O Shimomura, K Teranishi
May 1, 1960·Archives of Biochemistry and Biophysics·H H SELIGER, W D McELROY
Feb 25, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bakhos A TannousXandra O Breakefield
Mar 23, 2005·Nature Methods·Julie PerroyMichel Bouvier
Jul 22, 2006·Protein Engineering, Design & Selection : PEDS·Andreas Markus LoeningSanjiv Sam Gambhir
Feb 7, 2007·The Journal of Biological Chemistry·Lily I JiangPaul C Sternweis
Jul 10, 2007·Nature Methods·Andreas Markus LoeningSanjiv Sam Gambhir
Aug 7, 2007·Angewandte Chemie·Hequan YaoJianghong Rao
Aug 28, 2007·Angewandte Chemie·Akira KannoTakeaki Ozawa
Jan 22, 2008·Nature Methods·Thomas WurdingerBakhos A Tannous
Feb 23, 2008·Chemistry & Biology·Arnaud GautierKai Johnsson
Jun 7, 2008·ACS Chemical Biology·Georgyi V LosKeith V Wood
Jul 1, 2008·Nature Methods·Paulina CarribaRafael Franco
Mar 21, 2009·Current Opinion in Biotechnology·Brock BinkowskiKeith Wood
Apr 9, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Abhijit DeSanjiv Sam Gambhir
Aug 1, 2009·Bioconjugate Chemistry·Anca Dragulescu-AndrasiJianghong Rao
Dec 30, 2009·Nature Methods·Andreas Markus LoeningSanjiv Sam Gambhir
Apr 7, 2010·PloS One·Yoshihiro NakajimaYoshihiro Ohmiya
Oct 20, 2010·FEMS Microbiology Reviews·Nuria AndreuSiouxsie Wiles
Dec 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Genevieve C Van de BittnerChristopher J Chang
Dec 15, 2010·Annual Review of Marine Science·Steven H D HaddockJames F Case
Feb 24, 2011·Current Pharmaceutical Biotechnology·Abhijit De
Jul 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anca Dragulescu-AndrasiSanjiv S Gambhir
Jul 26, 2011·Nature Chemical Biology·Eneko UrizarJonathan A Javitch
Sep 29, 2011·Analytical Chemistry·Sung Bae KimHiroaki Tao
Feb 22, 2012·Angewandte Chemie·Nicholas R ConleyW E Moerner
Mar 1, 2012·Theranostics·Gae Baik Kim, Young-Pil Kim
Jul 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincent CompanPablo Pelegrin

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Citations

Sep 4, 2019·Angewandte Chemie·Dalu ChangNicolas Winssinger
Nov 26, 2019·Chemistry : a European Journal·Eloi P CoutantYves L Janin
Dec 15, 2019·Nature Communications·Alejandro Sarrion-PerdigonesKoen J T Venken
Apr 3, 2020·Micromachines·Muqsit Pirzada, Zeynep Altintas
Feb 8, 2020·Annual Review of Analytical Chemistry·Mai YamagishiYoshitaka Shirasaki
Jul 6, 2020·Apoptosis : an International Journal on Programmed Cell Death·Zhijing XuFu Wang
Nov 3, 2020·Chemistry : a European Journal·Glwadys GagnotYves L Janin
Feb 19, 2021·Biochemistry·Sierra J WilliamsJennifer A Prescher
Jan 28, 2021·Nature·Alfredo Quijano-RubioDavid Baker
Mar 18, 2021·ACS Chemical Biology·Colin M RathbunJennifer A Prescher
Aug 17, 2020·Cell Chemical Biology·Anna C Love, Jennifer A Prescher
Aug 14, 2020·Journal of the American Chemical Society·Zi YaoJennifer A Prescher
Dec 10, 2020·Trends in Biotechnology·Alexander Gräwe, Viktor Stein
Jun 16, 2021·Nature Communications·Andrea SchenkmayerovaJiri Damborsky
Aug 3, 2021·Journal of Neuroscience Methods·Crystian I MassengillHaining Zhong
Oct 2, 2019·ACS Omega·Alexander R FrenchMathew Tantama
Oct 9, 2019·Accounts of Chemical Research·Sierra J Williams, Jennifer A Prescher
Jun 18, 2021·Chembiochem : a European Journal of Chemical Biology·Caroline K BrennanJennifer A Prescher
Feb 28, 2019·Biochemistry·Hsien-Wei YehHui-Wang Ai
Apr 11, 2019·ACS Chemical Biology·Hsien-Wei YehHui-Wang Ai
Jan 8, 2020·Bioconjugate Chemistry·Simone F A WoutersMaarten Merkx
Aug 10, 2021·The Plant Journal : for Cell and Molecular Biology·Philippe V JutrasRenier A L van der Hoorn
Oct 15, 2020·ACS Sensors·Hope Adamson, Lars J C Jeuken
Nov 16, 2021·ACS Chemical Biology·Shirley LiuJohn A Ronald

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Methods Mentioned

BETA
biosensors
BRET
biosensor
biosensing
transfection
ubiquitination
CLASH
FRET
electron exchange
bioluminescence

Software Mentioned

CAMYEL
CoelPhos
BLI
CLASH
LOTUS

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