Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid

Chemical Communications : Chem Comm
Mitsuyasu KawaguchiHidehiko Nakagawa

Abstract

Nitroxyl (HNO) is a gaseous molecule with unique pharmacological functions distinct from those of nitric oxide. Because HNO is highly reactive with biological molecules, spatiotemporally controllable HNO releasers are required. Herein, we report the first visible-light-controllable HNO releasers, based on caged Piloty's acid, and we demonstrate their applicability in living cells.

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Citations

Aug 28, 2021·Chemical Science·Cecilia Mariel GallegoFabio Doctorovich
Sep 25, 2021·Photochemistry and Photobiology·Jayme CannonSeok Ki Choi

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Methods Mentioned

BETA
NMR
irradiated
fluorescence microscopy
Fluorescence

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