Development and characterisation of soluble polymeric particles for pulmonary peptide delivery

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Frederic TewesAnne Marie Healy

Abstract

Pulmonary administration of protein and peptide drugs using inhaled dry powder particles is an interesting alternative to parenteral delivery. The stabilisation of these molecules is essential to the maintenance of biological activity in such inhalation formulations. Here salmon calcitonin (sCT) was co-spray dried with linear or branched PEG (L-PEG and B-PEG) and PVP in order to formulate aerosolisable particles of the bioactive peptide. Co-spray drying L-PEG and PVP resulted in porous particles, with minimal D(50) (median volume diameter) and MMAD (mass median aerodynamic diameter) values obtained for a PEG/PVP w/w ratio of 1. For particles based on both L-PEG and B-PEG, an increase in acetone, a poor solvent for the PVP, up to 70wt% of the spray dried solution led to a decrease in D(50) and MMAD. Crystallinity of PEG in the particles ranged between 90 and 97% when the PVP content varied between 15 and 70wt%, indicating a low degree of interaction between PVP and PEG. Additionally, dynamic vapour sorption analysis showed that an increase in PVP content increased the particle surface hygroscopicity. Hence, particle properties were adjusted by altering the water/acetone and PEG/PVP ratio in the spray dried solutions. PVP present...Continue Reading

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Citations

Apr 9, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Frederic TewesAnne Marie Healy
Sep 3, 2011·Molecular Pharmaceutics·Frederic TewesAnne Marie Healy
Nov 21, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Janani SwaminathanCarsten Ehrhardt
Apr 17, 2014·Advanced Drug Delivery Reviews·Anne Marie HealyLidia Tajber
Dec 23, 2015·ACS Applied Materials & Interfaces·Frederic TewesAnne Marie Healy
Sep 22, 2015·International Journal of Pharmaceutics·Mohammed ManiruzzamanDennis Douroumis
Aug 14, 2012·The Journal of Pharmacy and Pharmacology·Francesca UngaroFabiana Quaglia
Oct 4, 2011·International Journal of Pharmaceutics·Maria Inês AmaroAnne Marie Healy
Aug 21, 2013·International Journal of Pharmaceutics·Stefano BiancoAnne Marie Healy
Feb 25, 2014·International Journal of Pharmaceutics·Seyed Salman Razavi RohaniMohsen Tafaghodi
Sep 24, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Frederic TewesAnne Marie Healy
Dec 21, 2014·International Journal of Pharmaceutics·Ahmad S BarhamAnne Marie Healy
Jun 8, 2018·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ayca Yildiz-PeközErdal Cevher
Jun 21, 2020·Pharmaceutics·Frédéric TewesSandrine Marchand
Apr 13, 2021·Advanced Drug Delivery Reviews·Dongmei CunMingshi Yang
Jun 19, 2021·AAPS PharmSciTech·Basanth Babu EedaraHeidi M Mansour
Aug 18, 2020·International Journal of Pharmaceutics·Érika Yoko SuzukiValeria Pereira de Sousa
Aug 22, 2018·International Journal of Pharmaceutics·Érika Yoko SuzukiValeria Pereira de Sousa

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