Development and characteristics of a synovial-like interface membrane around cemented tibial hemiarthroplasties in a novel rat model of aseptic prosthesis loosening

Arthritis and Rheumatism
G PapT Pap

Abstract

Aseptic prosthesis loosening (APL) is related to the formation and aggressive growth of a synovial-like interface membrane (SLIM) between prosthesis and bone. However, investigation of the early phases of SLIM development in humans presents major difficulties. This study was undertaken to develop and characterize the usefulness of a novel animal model of APL that is based on an established model of defined exercise in a running wheel by Wistar rats that have been subjected to intracranial self-stimulation (ICSS). Cemented tibial hemiarthroplasties were implanted into the left knees of 7 male Wistar rats. After 2 weeks, exercise in a running wheel was started in all rats, with a running-load of 2 hours/day for 5 days/week. Six months postoperatively, the knee joints were removed, decalcified, and embedded in paraffin. Histologic evaluation on hematoxylin and eosin-stained sections was performed to investigate the development of a SLIM and the presence of cement debris particles. To characterize the SLIM on a molecular level and investigate growth-regulating factors, the expression of transforming growth factor beta (TGFbeta) and the anti-apoptotic molecule Bcl-2 was analyzed by immunohistochemistry. Although the prostheses appea...Continue Reading

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Citations

Nov 12, 2010·International Orthopaedics·Jean Langlois, Moussa Hamadouche
Oct 7, 2006·Der Pathologe·M OttoS Bertz
Dec 14, 2005·Current Opinion in Rheumatology·R John LooneyRegis J O'Keefe
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May 27, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Meghan M MoranDale Rick Sumner
Dec 6, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Aaron SchindelerDavid G Little
Jan 16, 2004·Gene Therapy·P H Wooley, E M Schwarz
Apr 14, 2018·BioMed Research International·Hao XuYing-Zhen Wang
Jun 18, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kenneth A MannMegan E Oest
Jan 1, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kenneth A MannMegan E Oest
Nov 26, 2009·The Orthopedic Clinics of North America·Véronique ViateauPhilippe Pélissier

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