PMID: 8978658Jan 1, 1997Paper

Development and characterization of a biodegradable polyphosphate

Journal of Biomedical Materials Research
M L Renier, D H Kohn

Abstract

A biodegradable polyphosphate polymer (Mn = 18,000, Mw/Mn = 3.2) matrix system was developed as a potential delivery vehicle for growth factors. As a model system, release of recombinant human osteogenic protein-1 (OP-1) from this polymer was evaluated. The polyphosphate was synthesized using a triethylamine catalyst in an argon environment, and characterized using elemental analysis, gel permeation chromatography (GPC), and Fourier transform infrared spectroscopy (FTIR). Degradation kinetics of the polyphosphate polymer in phosphate-buffered saline (PBS) were represented by a second-order polynomial while degradation in bovine serum was linear with time. The polymer degraded faster in PBS than in bovine serum. In vitro release of OP-1 was also faster in PBS than in serum. Release kinetics of OP-1 in PBS and serum were represented by second-order polynomials. The OP-1 release from this physically dispersed polymeric matrix may be described by several possible mechanisms: diffusion, bulk polymer degradation, ion complexation, and interactions among the protein (OP-1), polymer, proteins, and enzymes in the media. This polyphosphate may be an effective carrier for morphogens, growth factors, or other classes of bioactive molecules.

Citations

Jun 7, 2005·Cytokine & Growth Factor Reviews·Howard Seeherman, John M Wozney
Oct 10, 2007·Micron : the International Research and Review Journal for Microscopy·João Paulo Mardegan IssaWalter Sebald
Apr 22, 2004·The Journal of Pharmacy and Pharmacology·Felicity R A J RoseRichard O C Oreffo
Sep 3, 2002·Spine·Howard SeehermanRebecca Li
Jul 13, 2004·Drug Development and Industrial Pharmacy·Hiroo MaedaKeiji Fujioka
Feb 12, 2019·The ISME Journal·Alejandra Guadalupe Acosta-CortésJuan Francisco Villarreal-Chiu
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Yuichi MurayamaLuisa Iruela-Arispe
Mar 15, 2003·Journal of Biomaterials Science. Polymer Edition·Mahesh V ChaubalZhong Zhao
Feb 7, 2017·Chemical Society Reviews·Nane VanparijsBruno G De Geest
Dec 12, 2007·Anatomia, histologia, embryologia·J P M IssaR F De Albuquerque
Jun 6, 2019·Macromolecular Bioscience·Rafael DeraThomas J Cleij
Sep 30, 2009·Journal of the American Society for Mass Spectrometry·Malgorzata A Kaczorowska, Helen J Cooper
May 11, 2011·Biomacromolecules·Sophie MongeJean-Jacques Robin
Feb 11, 2020·Analytical Chemistry·Jonas Johannes ChristLars M Blank
May 11, 2004·Biomacromolecules·Yasuhiko IwasakiKazunari Akiyoshi

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