PMID: 6968913Sep 1, 1980Paper

Development and characterization of allospecific long-term human cytolytic T-cell lines

Proceedings of the National Academy of Sciences of the United States of America
C S ReissS J Burakoff

Abstract

Two long-term human cytolytic T lymphocyte (CTL) lines (VE and JR), whose cytolytic activity was dependent upon both irradiated JY cells (the stimulating alloantigen) and T-cell growth factor, were established. These lines were monitored in culture for 6-8 months. Both lines were specific for HLA-A or B antigens or both and the JR line was allospecific for HLA-B7. These CTL lines killed specific target cells at an effector-to-target ratio of 0.4 (VE) or 0.08 (JR). All of the cells, which grow in suspension, rosetted with sheep erythrocytes and reacted with an antiserum specific for human T cells. The CTL line VE was used to raise rabbit antisera that immunoprecipitated two specific polypeptides (78,000 and 33,000 daltons) from labeled membranes of these CTL lines.

References

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Citations

Jun 1, 1989·Cellular Immunology·M M KhanA M Krensky
Jan 1, 1981·International Journal of Immunopharmacology·T CotnerJ L Strominger
Jan 1, 1984·Human Immunology·R B Effros, R L Walford
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F Sanchez-MadridT A Springer
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A M KrenskyS J Burakoff
Jun 1, 1983·The Journal of Pediatrics·A M Krensky, S J Burakoff
Aug 15, 1981·International Journal of Cancer. Journal International Du Cancer·K SugamuraY Hinuma
Mar 1, 1986·Microbiological Reviews·F W Fitch

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