PMID: 11337157May 5, 2001Paper

Development and characterization of lipid microparticles as a drug carrier for somatostatin

International Journal of Pharmaceutics
H ReithmeierA Göpferich

Abstract

Somatostatin, a therapeutic peptide with a high therapeutical potential but a very short biological half-live was encapsulated within microparticles by a modified solvent evaporation method and a melt dispersion method without the use of organic solvent. As the use of synthetic polymer matrix materials often goes along with detrimental effects on incorporated peptides, we investigated the potential of physiological lipids such as glyceryl tripalmitate (Dynasan 116) as an alternative matrix material. The two preparation methods were evaluated with respect to surface topography, particle size distribution, encapsulation efficiency, in-vitro release behavior and modification of the resulting microparticles. Microparticles with a suitable particle size distribution for i.m. or s.c. injection could be prepared with both methods. The encapsulation efficiency of the peptide into glyceryl tripalmitate microparticles was substantially influenced by the preparation method and the physical state of the peptide to be incorporated. The melt dispersion technique and the incorporation of the drug as an aqueous solution gave the best results with actual drug loadings up to 9% and an encapsulation efficiency of approximately 90%. Microparticles...Continue Reading

References

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·A Rothen-WeinholdR Gurny
Mar 25, 1999·International Journal of Pharmaceutics·C Olbrich, R H Müller
Sep 2, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Rothen-WeinholdR Gurny
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerS Gohla

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Citations

Aug 6, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P C ChristophersenH Mu
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·M D Del CurtoP Esposito
Feb 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Manju RawatSwarnlata Saraf
Dec 7, 2011·Scientia pharmaceutica·Basavaraj K NanjwadeFakirappa V Manvi
May 28, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jayaganesh V NatarajanSubbu Venkatraman
Nov 14, 2014·Expert Opinion on Drug Delivery·Santo ScaliaDaniela Traini
Nov 22, 2005·Expert Opinion on Drug Delivery·Yi Shi, Luk Chiu Li
Jun 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yvonne RosiauxDelphine Marchaud
May 1, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lorenzo CaprettoClaudio Nastruzzi
Apr 13, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·S KoenningsA Goepferich
Oct 31, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Angelika MaschkeAchim Göpferich
Mar 1, 2006·International Journal of Pharmaceutics·C GuseJ Siepmann
Mar 4, 2006·International Journal of Pharmaceutics·S KoenningsA Goepferich
Dec 17, 2011·Journal of Drug Delivery·Patrícia SeverinoEliana B Souto
Sep 24, 2013·BioMed Research International·Praveen Kumar GaurSuresh Purohit
Nov 22, 2005·Expert Opinion on Drug Delivery·Séverine JaspartBrigitte Evrard
Jul 8, 2015·Therapeutic Delivery·Anthony A Attama, Chukwuebuka E Umeyor
Mar 30, 2007·Journal of Microencapsulation·Spomenka MilakIan G Tucker
Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Vita LaroccaCarla Ferreri
Apr 1, 2003·Pharmaceutical Development and Technology·W VogelhuberA Göpferich
May 30, 2014·Jundishapur Journal of Natural Pharmaceutical Products·Lana TamaddonFahimeh Asadi Amoli
Nov 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara YazdiDavid Putnam
Jun 3, 2021·Pharmaceutics·Seth P ForsterTiffany Chiang
Feb 6, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandra HerrmannJuergen Siepmann
Mar 2, 2002·Science·I G LoscertalesA M Gañán-Calvo

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