Development and characterization of Poly (vinyl alcohol) based hydrogels for potential use as an articular cartilage replacement

Materials Science & Engineering. C, Materials for Biological Applications
Adolfo Sebastián MaioloVera A Alvarez

Abstract

Hydroxyapatite (HA) reinforced Poly(vinyl alcohol) (PVA) hydrogel composites has been proposed as a promising biomaterial to replace diseased or damaged articular cartilage. Here, PVA/in-situ produced HA hydrogels with 0, 3 and 7.5 wt.% of HA content were obtained by freezing/thawing technique. Thermal, structural and mechanical characterizations were carried out. SEM micrographs revealed that HA was homogeneously distributed in PVA until 3 wt.% whereas partial agglomeration was observed for higher contents (7.5 wt.%). No significant changes were observed in the glass transition temperature (the average value was near to 78 °C ± 3 °C), the melting point and structural water content whereas the gel fraction slightly increased (from 0.72 to 0.78) with the increase the content of HA. The absorbed water decreased (from 85.7% to 80.5%) as a function of HA content The stress-strain curves were really different in hydrated and non-hydrated conditions, changing from non-linear, in presence of water, to linear behavior in a dried state, being in the first case consistent with the articular cartilage . The lowest friction coefficient was obtained for samples with 3 wt. % HA (0.067 ± 0.049), which is, together with a high resistance (721 ...Continue Reading

References

Dec 18, 2004·Biomaterials·Masanori KobayashiMasanori Oka
Sep 12, 2006·Biomaterials·Daniela EyrichTorsten Blunk

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Citations

Dec 17, 2014·Journal of Biomaterials Science. Polymer Edition·Jeong Eun SongGilson Khang
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Xue-Hua ZhouQiong Zhou
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Yahui MaFei Wang
Dec 4, 2014·Colloids and Surfaces. B, Biointerfaces·Zhiyong LiChangcheng He
Jul 22, 2014·Materials·Azadehsadat Hashemi DoulabiHadi Mohammadi
Mar 20, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Austyn R MathesonTannin A Schmidt
Jun 8, 2021·International Journal of Biological Macromolecules·Mohammad Nouri-FelekoriTayebe Ramezani
Aug 19, 2021·Journal of Materials Science. Materials in Medicine·Jie XieYihe Hu

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