Development and cytolytic function of intestinal intraepithelial T lymphocytes in antigen-minimized mice

Immunology
M Kawaguchi-MiyashitaM Ohwaki

Abstract

Intraepithelial T lymphocytes in the small intestine (IEL) consist of alpha beta T-cell receptor (TCR)-bearing T cells (alpha beta-IEL) and gamma delta TCR-bearing T cells (gamma delta-IEL). Development and cytolytic activation of alpha beta-IEL sharply attenuate in germ-free (GF) mice fed a natural diet (Nat-GF), but the number and cytotoxicity of gamma delta-IEL are comparable between conventional (CV) and Nat-GF mice. In this report, we compared the properties of IEL in Nat-GF mice and GF mice fed antigen-minimized diet (AgM-GF mice) of C57BL/6 strain to evaluate an influence of gut antigenic load on IEL development. Numbers of alpha beta-IEL and gamma delta-IEL in AgM-GF mice were less by 1.9- and 1.4-fold than those in Nat-GF mice, respectively. Significant decreases in the proportions of CD4+8-, CD4-8 alpha beta +, and CD4+8+ subsets and a resultant increase in the ratio of CD4-8 alpha alpha + subset were evident in alpha beta-IEL of Nat-GF mice compared with CV mice, but the subset constitution of alpha beta-IEL was similar between Nat-GF and AgM-GF mice. In contrast, relative composition of gamma delta-IEL was not different between CV, Nat-GF, and AgM-GF mice. alpha beta-IEL displayed low cytolytic activity in Nat-GF mi...Continue Reading

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Citations

Sep 2, 1998·Immunologic Research·M NannoH Ishikawa
Jan 16, 2013·Immunology and Cell Biology·Yoshiyuki Goto, Ivaylo I Ivanov
Apr 1, 1997·Immunological Reviews·A M Mowat, J L Viney
Dec 3, 1999·Immunological Reviews·J C SirardJ P Kraehenbuhl
Mar 3, 2010·Annual Review of Immunology·David A Hill, David Artis
Apr 14, 2000·Neurosurgery·I F ParneyK C Petruk
Jun 26, 2003·Neurosurgery·Aaron S DumontKevin S Lee
Mar 13, 2009·PLoS Biology·Emmanuel MartinOlivier Lantz
Mar 29, 2000·Biochemical and Biophysical Research Communications·J FritscheM Kreutz
Jan 7, 2014·Annual Review of Immunology·Yueh-hsiu ChienMarc Bonneville
Jun 9, 2007·Scandinavian Journal of Medicine & Science in Sports·F KimuraI Kono
Feb 24, 2012·Gut Microbes·Hsin-Jung Wu, Eric Wu
Aug 15, 2014·Frontiers in Immunology·Darina S Spasova, Charles D Surh
Mar 27, 2003·Nature Reviews. Immunology·Matthias G von Herrath, Leonard C Harrison
Sep 12, 2019·Immunology·Amelia T Soderholm, Virginia A Pedicord
May 3, 2002·Clinical and Diagnostic Laboratory Immunology·Naoto ItohYasunobu Yoshikai
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kirk D C JensenYueh-Hsiu Chien
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Jul 3, 2020·Frontiers in Immunology·Jayne E WiardaCrystal L Loving
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·N CorazzaC Mueller

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