Development and evaluation of a crowdsourcing methodology for knowledge base construction: identifying relationships between clinical problems and medications.

Journal of the American Medical Informatics Association : JAMIA
A McCoyDean F Sittig

Abstract

We describe a novel, crowdsourcing method for generating a knowledge base of problem-medication pairs that takes advantage of manually asserted links between medications and problems. Through iterative review, we developed metrics to estimate the appropriateness of manually entered problem-medication links for inclusion in a knowledge base that can be used to infer previously unasserted links between problems and medications. Clinicians manually linked 231,223 medications (55.30% of prescribed medications) to problems within the electronic health record, generating 41,203 distinct problem-medication pairs, although not all were accurate. We developed methods to evaluate the accuracy of the pairs, and after limiting the pairs to those meeting an estimated 95% appropriateness threshold, 11,166 pairs remained. The pairs in the knowledge base accounted for 183,127 total links asserted (76.47% of all links). Retrospective application of the knowledge base linked 68,316 medications not previously linked by a clinician to an indicated problem (36.53% of unlinked medications). Expert review of the combined knowledge base, including inferred and manually linked problem-medication pairs, found a sensitivity of 65.8% and a specificity of ...Continue Reading

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Citations

Jun 21, 2013·Bioinformatics·Benjamin M Good, Andrew I Su
Apr 9, 2013·Journal of the American Medical Informatics Association : JAMIA·Kavishwar Balwant WagholikarRajeev Chaudhry
Apr 2, 2013·Journal of the American Medical Informatics Association : JAMIA·Adam WrightDean F Sittig
Feb 24, 2016·Journal of Biomedical Informatics·Hsin-Min LuFei-Yuan Hsiao
Sep 23, 2014·Journal of Biomedical Informatics·Aileen P WrightDean F Sittig
Apr 19, 2015·Briefings in Bioinformatics·Ritu KhareZhiyong Lu
Dec 21, 2013·Journal of Biomedical Informatics·Jeffrey G KlannGunther Schadow
Sep 16, 2014·Journal of Biomedical Informatics·Ritu KhareZhiyong Lu
Mar 24, 2015·Database : the Journal of Biological Databases and Curation·Ritu KhareZhiyong Lu
Mar 5, 2016·Clinical Pharmacology and Therapeutics·S HussainP H O'Donnell
Feb 11, 2015·Journal of the American Medical Informatics Association : JAMIA·Catherine PlaisantBen Shneiderman
Sep 4, 2015·Journal of the American Medical Informatics Association : JAMIA·Hojjat SalmasianCarol Friedman
Sep 25, 2017·ELife·Daniel Scott HimmelsteinSergio E Baranzini
Sep 8, 2018·Health Informatics Journal·Max H SimsMarc W Halterman
Nov 7, 2018·American Journal of Speech-language Pathology·Hayo TerbandBen Maassen
May 1, 2019·BMC Bioinformatics·Mohamed Reda BouadjenekKarin Verspoor
May 17, 2018·Journal of Medical Internet Research·Perrine CréquitPhilippe Ravaud
Aug 2, 2018·BMC Medical Informatics and Decision Making·Juan Antonio Lossio-VenturaJiang Bian
Nov 6, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pavan A VaswaniNabila Dahodwala
Sep 25, 2021·Scientific Reports·Neil S ZhengWei-Qi Wei

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