Abstract
Photodynamic therapy (PDT) using δ-aminolevulinic acid (ALA) photosensitization has shown promise in clinical studies for the treatment of early-stage oral malignancies with fewer potential side effects than traditional therapies. Light delivery to oral lesions can also carried out with limited medical infrastructure suggesting the potential for implementation of PDT in global health settings. We sought to develop a cost-effective, battery-powered, fiber-coupled PDT system suitable for intraoral light delivery enabled by smartphone interface and embedded electronics for ease of operation. Device performance was assessed in measurements of optical power output, spectral stability, and preclinical assessment of PDT response in ALA-photosensitized squamous carcinoma cell cultures and murine subcutaneous tumor xenografts. The system achieves target optoelectronic performance with a stable battery-powered output of approximately 180 mW from the fiber tip within the desired spectral window for PpIX activation. The device has a compact configuration, user friendly operation and flexible light delivery for the oral cavity. In cell culture, we show that the overall dose-response is consistent with established light sources and complete ...Continue Reading
References
Jul 17, 1993·Lancet·W E GrantS G Bown
Oct 1, 1996·Cancer·K F FanS G Bown
May 1, 1997·Radiation Research·B W Pogue, T Hasan
Mar 10, 1998·Journal of Photochemistry and Photobiology. B, Biology·S MüllerU Haller
Dec 30, 1998·International Journal of Oral and Maxillofacial Surgery·A KüblerJ Mühling
Jul 29, 2000·Biochimica Et Biophysica Acta·J DahleJ Moan
Feb 15, 2001·Journal of Agricultural and Food Chemistry·M J MorenoA Montoya
May 2, 2003·Nature Reviews. Cancer·Dean W Felsher
Aug 2, 2003·Technology in Cancer Research & Treatment·Pei-Jen LouColin Hopper
Feb 3, 2004·Lasers in Surgery and Medicine·Jui-Chang TsaiTsuimin Tsai
Oct 8, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Brad Rodu, Christer Jansson
Jul 23, 2005·Lasers in Surgery and Medicine·Hsin-Ming ChenChun-Pin Chiang
Oct 10, 2009·Lasers in Surgery and Medicine·Chuan-Hang YuChun-Pin Chiang
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Oct 25, 2012·Journal of Cancer Epidemiology·Ken Russell Coelho
Dec 4, 2012·Photodiagnosis and Photodynamic Therapy·Florent PoyerJoël Mispelter
Jan 18, 2014·Scientific Reports·Jonathan P CelliTayyaba Hasan
Apr 25, 2015·Journal of Biomedical Optics·Srivalleesha MallidiTayyaba Hasan
May 13, 2015·Scientific Reports·Joshua HempsteadJonathan P Celli
Jun 4, 2015·Photochemistry and Photobiology·Shannon M Gallagher-ColomboTheresa M Busch
Feb 13, 2016·Arthritis Care & Research·Doyt L Conn
Citations
Feb 23, 2020·Photochemistry and Photobiology·Edward V Maytin, Tayyaba Hasan
Nov 12, 2019·Lasers in Surgery and Medicine·Shuang ZhaoLisha Wu
Dec 11, 2019·Journal of Biomedical Optics·Alberto J RuizBrian W Pogue
Jul 28, 2020·Sensors·Jiayu Wang, Jianfei Dong
Nov 5, 2019·Scientific Reports·Srivalleesha MallidiTayyaba Hasan
Nov 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krzysztof ZduniakPiotr Ziółkowski
Apr 4, 2021·Pharmaceuticals·Yo ShinodaYasuyuki Fujiwara
Apr 25, 2021·Photodiagnosis and Photodynamic Therapy·Muhammed Ajmal