Development and evaluation of a novel pellet-based tablet system for potential colon delivery of budesonide.

Journal of Drug Delivery
Jaleh VarshosazFarid Dorkoosh

Abstract

Budesonide, a potent glucocorticoid, is used for the treatment of inflammatory bowel diseases. Current available oral formulations of budesonide have low efficacy against ulcerative colitis because of the premature drug release in the upper part of the gastrointestinal tract. In this paper a pH- and time-controlled colon-targeted pellet-based tablet of budesonide was established. Pellet cores were prepared by extrusion-spheronization method and further coated with xanthan gum (barrier layer), Eudragit NE30D and L30D55 combination (inner layer), and Eudragit FS30 (as enteric layer) sequentially to achieve the required release profile. The coated pellets then compressed into tablets using inert tabletting granules of Cellactose or Pearlitol. Release studies, performed in simulated gastric, intestinal, and colon pH were used in sequence to mimic the gastrointestinal transit. The influence of formulation variables like barrier layer thickness, inner layer composition, and enteric coat thickness on drug release were investigated and the coated pellets that contained 12% weight gain in xanthan gum layer, Eudragit L30D55 and Eudragit NE30D with a ratio of 3 : 7 in inner layer with 30% weight gain and 25% weight gain in Eudragit FS lay...Continue Reading

References

Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K G WagnerP C Schmidt
Apr 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ranjana ChopraGöran Alderborn
Nov 24, 2004·Advanced Drug Delivery Reviews·Ulrich Klotz, Matthias Schwab
Feb 12, 2008·Clinical and Experimental Dermatology·L F Montes
Nov 3, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Branka IvićZorica Djurić
Feb 16, 2011·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Martyn Patfield
Mar 29, 2011·The Australian Journal of Rural Health·UNKNOWN National Rural Health Alliance
Jul 1, 2011·International Journal of Pharmaceutical Investigation·Dasharath M PatelChhagan N Patel

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Citations

Mar 15, 2019·Critical Reviews in Analytical Chemistry·Milena Carla EspositoMagali Benjamim de Araújo
Jan 1, 2016·Journal of Nanomaterials·Diane RenderVijaya Rangari

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