Development and evaluation of alginate-chitosan nanocapsules for controlled release of acetamiprid

International Journal of Biological Macromolecules
Sandeep KumarNeeraj Dilbaghi

Abstract

Smart formulations based on nanomaterials have the capability to reduce the consumption of hazardous pesticides and their impact on human health and environment. Nanoformulations of agrochemicals have the potential to improve food productivity without compromising with the ecosystem. In the present work, controlled release nanocapsules containing acetamiprid were prepared by polyelectrolyte complexation of two natural macromolecules, i.e. alginate and chitosan. The size, morphology and chemical interaction studies of the prepared nanocapsules were investigated by Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM), and Fourier Transform Infrared Spectroscopy (FTIR). The zetapotential studies revealed stability of the nanocapsules. TEM results show spherical morphology of the nanocapsules. The encapsulation efficiency was found to be 62% as quantified by Ultra High Pressure Liquid Chromatography (UHPLC). Nanocapsules were analysed for controlled release in vitro at three different pH. Maximum release was observed at pH 10 followed by pH 7 and 4, respectively. A non-Fickian release mechanism was found to be followed by the nanoformulation. A controlled release pattern was also found from nanoformulation as comp...Continue Reading

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Citations

Apr 5, 2016·International Journal of Biological Macromolecules·A KamariS N M Yusoff
Oct 21, 2016·Environmental Science and Pollution Research International· SandhyaNeeraj Dilbaghi
Apr 3, 2019·Environmental Science and Pollution Research International·Chan ZhangLiangqi Zhao
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