Development and Evaluation of Artesunate-Loaded Chitosan-Coated Lipid Nanocapsule as a Potential Drug Delivery System Against Breast Cancer

AAPS PharmSciTech
Tuan Hiep TranChien Ngoc Nguyen

Abstract

Artesunate (ART)--a well-known hydrophobic anti-malarial agent was incorporated in a polymer-lipid hybrid nanocolloidal system for anti-cancer therapeutic. The lipid negatively charged nanoemulsion was formulated by modified hot homogenization method then covered with positively charged chitosan via electrostatic interaction to obtain chitosan-coated lipid nanocapsule (ART-CLN). Physical properties of the system were characterized in terms of size, charge, morphology, drug loading capacity, and physical state. In addition, anti-cancer activities were confirmed by conducting MTT assay for ART and ART-CLN on different cancer cell lines. Obtained ART-CLN after coating chitosan revealed positive charge (13.2 ± 0.87 mV), small particle size (160.9 ± 3.5 nm), and spherical shape. High drug entrapment efficiency (95.49 ± 1.13%) and sustained release pattern were observed. Moreover, the good cellular uptake was recorded by flow cytometry as well as confocal image. Finally, ART-CLN exhibited stronger anti-cancer activity than free ART on breast cancer cell lines (MCF-7, MDA-MB-231). These results suggested that by loading ART into lipid core of polymer-lipid hybrid carrier, the activity and physical stability of ART can be significantly...Continue Reading

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Citations

Feb 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Blessing Atim Aderibigbe
Apr 3, 2018·Biological & Pharmaceutical Bulletin·Katsunori TsudaKoichiro Tsuchiya
Nov 18, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Ives Charlie-SilvaNathalie Ferreira Silva de Melo
Jul 31, 2019·Drug Delivery·Muhammad Muzamil KhanHassan Shah
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Apr 11, 2018·Natural Products and Bioprospecting·Yunqin ZhangZhili Zuo
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Sep 21, 2021·Oncology Letters·Xiulan YangJie Zhang

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