Development and evaluation of carvedilol-loaded transdermal drug delivery system: In-vitro and in-vivo characterization study

Drug Development and Industrial Pharmacy
Sanjay J KshirsagarSantosh K Mohapatra

Abstract

The transdermal drug delivery system was prepared and the bioavailability of the selected drug was enhanced by reducing first-pass metabolism. The objective of this study was to enhance the bioavailability of carvedilol through transdermal patches. To develop a matrix-type transdermal patch containing carvedilol with different ratios of polymer combinations by solvent evaporation technique. In-vitro permeation studies were performed by Franz diffusion cells. The results followed Higuchi kinetics, and mechanism of release was diffusion mediated. On the basis of the in-vitro and physicochemical parameters of carvedilol patches, the code F-1(PVP: Ethyl Cellulose = 4:1) was chosen for the study of in-vivo, ex-vivo, histocompatibility study, and pharmacological study. The bioavailability studies in rats indicated that the carvedilol-loaded transdermal patches provided steady-state plasma concentration and improved bioavailability of 72% in comparison to oral administration. The ex-vivo permeation study in rat's skin indicated that the flux and permeability co-efficient of optimized F-1 patch was 30.08 ± 0.7 μg/cm(2)/h and 0.416 ± 0.05 μg/cm(2)/h, respectively, which was more as compared to plain carvedilol. The histocompatibility st...Continue Reading

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Citations

Jun 26, 2013·International Journal of Pharmaceutics·Yuri Ikeuchi-TakahashiHiraku Onishi
Jun 12, 2014·Drug Development and Industrial Pharmacy·Federica BigucciBarbara Luppi
Dec 25, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Abdul AhadMohd Aqil
May 3, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Danhua LiuDan Yang
Dec 12, 2020·Journal of Microencapsulation·Najla Locatelli Santos EstevesStephânia Fleury Taveira
Aug 29, 2021·Pharmaceuticals·Szymon SipJudyta Cielecka-Piontek

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