Development and evaluation of co-formulated docetaxel and curcumin biodegradable nanoparticles for parenteral administration

Pharmaceutical Development and Technology
Harish PawarSarasija Suresh

Abstract

Technology for development of biodegradable nanoparticles encapsulating combinations for enhanced efficacy. To develop docetaxel (DTX) and curcumin (CRM) co-encapsulated biodegradable nanoparticles for parenteral administration with potential for prolonged release and decreased toxicity. Modified emulsion solvent-evaporation technique was employed in the preparation of the nanoparticles optimized by the face centered-central composite design (FC-CCD). The uptake potential was studied in MCF-7 cells, while the toxicity was evaluated by in vitro hemolysis test. In vivo pharmacokinetic was evaluated in male Wistar rats. Co-encapsulated nanoparticles were developed of 219 nm size, 0.154 PDI, -13.74 mV zeta potential and 67.02% entrapment efficiency. Efficient uptake was observed by the nanoparticles in MCF-7 cells with decreased toxicity in comparison with the commercial DTX intravenous injection, Taxotere®. The nanoparticles exhibited biphasic release with initial burst release followed by sustained release for 5 days. The nanoparticles displayed a 4.3-fold increase in AUC (391.10 ± 32.94 versus 89.77 ± 10.58 μg/ml min) in comparison to Taxotere® with a 6.2-fold increase in MRT (24.78 ± 2.36 versus 3.58 ± 0.21 h). The nanoparticle...Continue Reading

References

Aug 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D SchrijversS Kaye
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·K AvgoustakisD S Ithakissios
Mar 12, 2003·Advanced Drug Delivery Reviews·Jayanth Panyam, Vinod Labhasetwar
Feb 18, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·Bhupinder SinghNaveen Ahuja
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bharat B AggarwalJanet E Price
Dec 27, 2005·International Journal of Pharmaceutics·Vasiliki PapadopoulouPanos Macheras
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Oct 7, 2008·Cell Division·Gaurisankar Sa, Tanya Das
Sep 29, 2009·Colloids and Surfaces. B, Biointerfaces·Avnesh KumariSubhash C Yadav
Jul 16, 2010·Journal of Colloid and Interface Science·Murali Mohan YallapuSubhash C Chauhan
Oct 12, 2010·International Journal of Pharmaceutics·Dhananjay S SingareParchuri Srinivasa Rao
Jan 13, 2011·Journal of Chromatographic Science·Vinay Kumar VenishettyPrakash Vamanrao Diwan
Feb 23, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
May 23, 2012·Drug Development and Industrial Pharmacy·Yong Zhi ZhouJingyuan Wen
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal

❮ Previous
Next ❯

Citations

Dec 13, 2018·Frontiers in Pharmacology·Zhijun LiuChuanshan Xu
Apr 20, 2021·Colloids and Surfaces. B, Biointerfaces·Rajesh Singh JadonRajeev K Tyagi
Mar 7, 2020·Chemical Research in Toxicology·Mariana ColaçoOlga Borges

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.