Development and evaluation of lorazepam microemulsions for parenteral delivery.

AAPS PharmSciTech
Amit A Kale, Vandana Patravale

Abstract

The objective of this investigation was to develop lorazepam (LZM) microemulsions as an alternative to the conventional cosolvent based formulation. Solubility of LZM in various oils and Tween 80 was determined. The ternary diagram was plotted to identify area of microemulsion existence and a suitable composition was identified to achieve desired LZM concentration. The LZM microemulsions were evaluated for compatibility with parenteral fluids, globule size, in vitro hemolysis and stability of LZM. Capmul MCM demonstrated highest solubilizing potential for LZM and was used as an oily phase. LZM microemulsions were compatible with parenteral dilution fluids and exhibited mean globule size less than 200 nm. The in vitro hemolysis studies indicated that microemulsions were well tolerated by erythrocytes. The LZM microemulsions containing amino acids exhibited good physical and chemical stability when subjected to refrigeration for 6 months.

References

Jul 20, 1995·The New England Journal of Medicine·S N BennettL Stroud
Feb 1, 1997·Journal of Clinical Pharmacy and Therapeutics·M YalinA A Hincal
Jan 15, 2000·Critical Reviews in Therapeutic Drug Carrier Systems·S Tenjarla
Mar 21, 2000·International Journal of Pharmaceutics·W WarisnoicharoenM J Lawrence
Aug 17, 2000·Journal of Applied Microbiology·I S Al-AdhamP J Collier
Mar 29, 2001·International Journal of Pharmaceutics·J MedinaA del Pozo
Dec 14, 2001·AAPS PharmSci·W WarisnoicharoenM J Lawrence
Mar 23, 2004·Pharmaceutical Research·Robert G Strickley
Dec 21, 2004·International Journal of Pharmaceutics·Ping LiAbu T M Serajuddin
Aug 20, 2005·Drug Development and Industrial Pharmacy·Chantal HolvoetJacqueline Plaizier-Vercammen
Sep 18, 2007·International Journal of Pharmaceutics·Adwoa O NornooDiana S-L Chow
Feb 26, 2008·International Journal of Pharmaceutics·Abhijit A Date, M S Nagarsenker

❮ Previous
Next ❯

Citations

Sep 3, 2013·Journal of Neurology·Wilma S W WichardsFrans S S Leijten
Jul 28, 2013·International Journal of Pharmaceutics·Sushant PatilVandana Patravale
Dec 18, 2013·Therapeutic Delivery·Bharti SapraAshok K Tiwary
Jan 16, 2015·Biological & Pharmaceutical Bulletin·Sureewan DuangjitTanasait Ngawhirunpat
Jun 2, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sophie Yvette LeclercqSílvia Ligório Fialho
Jan 25, 2012·Journal of Drug Delivery·E MonteagudoA M Carlucci
Jul 31, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fitsum F SahleReinhard H H Neubert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Pharmaceutics
Abhijit A Date, Mangal S Nagarsenker
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Fitsum F SahleReinhard H H Neubert
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Colin W Pouton
© 2022 Meta ULC. All rights reserved