Development and evaluation of lorazepam microemulsions for parenteral delivery

AAPS PharmSciTech
Amit A Kale, Vandana Patravale

Abstract

The objective of this investigation was to develop lorazepam (LZM) microemulsions as an alternative to the conventional cosolvent based formulation. Solubility of LZM in various oils and Tween 80 was determined. The ternary diagram was plotted to identify area of microemulsion existence and a suitable composition was identified to achieve desired LZM concentration. The LZM microemulsions were evaluated for compatibility with parenteral fluids, globule size, in vitro hemolysis and stability of LZM. Capmul MCM demonstrated highest solubilizing potential for LZM and was used as an oily phase. LZM microemulsions were compatible with parenteral dilution fluids and exhibited mean globule size less than 200 nm. The in vitro hemolysis studies indicated that microemulsions were well tolerated by erythrocytes. The LZM microemulsions containing amino acids exhibited good physical and chemical stability when subjected to refrigeration for 6 months.

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Citations

Sep 3, 2013·Journal of Neurology·Wilma S W WichardsFrans S S Leijten
Jul 28, 2013·International Journal of Pharmaceutics·Sushant PatilVandana Patravale
Dec 18, 2013·Therapeutic Delivery·Bharti SapraAshok K Tiwary
Jan 16, 2015·Biological & Pharmaceutical Bulletin·Sureewan DuangjitTanasait Ngawhirunpat
Jun 2, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sophie Yvette LeclercqSílvia Ligório Fialho
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