Development and Evaluation of Stimuli-Responsive Chimeric Nanostructures

AAPS PharmSciTech
Nikolaos NazirisBarbara Trzebicka

Abstract

Chimeric/mixed stimuli-responsive nanocarriers are promising agents for therapeutic and diagnostic applications, as well as in the combinatorial field of theranostics. Herein, we designed chimeric nanosystems, composed of natural phospholipid and pH-sensitive amphiphilic diblock copolymer, in different molar ratios and assessed the polymer lyotropic effect on their properties. Initially, polymer-grafted bilayers were evaluated for their thermotropic behavior by thermal analysis. Chimeric liposomes were prepared through thin-film hydration and the obtained vesicles were studied by light scattering techniques, to measure their physicochemical characteristics and colloidal stability, as well as by imaging techniques, to elucidate their global and membrane morphology. Finally, in vitro screening of the systems' toxicity was held. The copolymer effect on the membrane phase transition strongly depended on the pH of the surrounding environment. Chimeric nanoparticles were around and above 100 nm, while electron microscopy revealed occasional morphology diversity, probably affecting the toxicity of the systems. The latter was assessed to be tolerable, while dependent on the nanosystems' material concentration, polymer concentration, an...Continue Reading

References

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Aug 26, 2016·Journal of Liposome Research·Nikolaos NazirisCostas Demetzos

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Citations

Nov 12, 2020·Materials·Nikolaos NazirisCostas Demetzos
Jul 3, 2021·International Journal of Molecular Sciences·Nikolaos NazirisCostas Demetzos

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Methods Mentioned

BETA
light scattering
size exclusion chromatography
differential scanning calorimetry
electrophoretic light scattering
atomic force microscopy
transmission electron microscopy
AFM
electron beam
imaging techniques

Software Mentioned

MALVERN
TIA
Veeco NanoScope
HSPC
Mettler STAR
SigmaPlot
EXCELL

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