Development and evaluation of targeting ligand-anchored CNTs as prospective targeted drug delivery system

Artificial Cells, Nanomedicine, and Biotechnology
Sumandeep KaurNarendra K Jain

Abstract

Our main investigation in the present research was to developt and evaluate targeting ligand-anchored multiwalled carbon nanotubes (MWCNTs) as prospective targeted drug delivery system, with a special focus on the MWCNTs surface functionalization (FA-PEG bis-amine functionalized, carboxylated MWCNTs). In vitro release of 5-fluorouracil (5-FU) was studied at pH 7.4 phosphate buffer and 5.5 acetate buffer, which displayed initial faster followed by sustained release up to 900 min. Further, 5-FU/FA-PEG bis amine-MWCNTs was found to be long circulating, prolonged half-life and increased drug accumulation in target tissue.

References

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Citations

Aug 23, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Sai Kiran S S PindiproluVeera Venkata Satyanarayana Reddy Karri
Oct 19, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Mehrdad SamadishadlouSepideh Mousavi
Jan 31, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Mehdi YoosefianNazanin Etminan
Jun 8, 2021·Colloids and Surfaces. B, Biointerfaces·Aida SolhjooAmirhossein Sakhteman
Jun 15, 2021·Journal of Materials Science. Materials in Medicine·Rutuja V KambleMangesh A Bhutkar

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