Development and evaluation of taste-masked drug for paediatric medicines - application to acetaminophen

International Journal of Pharmaceutics
Thanh Huong Hoang ThiMarie-Pierre Flament

Abstract

The aim of this work was to produce and characterize taste-masked powders of a model drug (acetaminophen) prepared using potentially tolerable and safe excipients for paediatric use, i.e. sodium caseinate and lecithin. The powders were produced by spray-drying aqueous dispersions. The characteristics of taste-masked drug particles were determined by scanning electron microscopy, differential scanning calorimetry and X-ray photoelectron spectroscopy to analyse the surface composition of particles. Taste assessment was approached by an indirect method through drug release studies. We developed a method with a syringe pump using small volumes of aqueous medium and low flow rates, to mimic the behaviour in the mouth. This method was compared to the electronic tongue analysis. SEM, DSC and XPS analysis indicated differences in surface composition of spray-dried particles according to the caseinate/lecithin ratio and to relate it with taste-masking. The "coating" consisting of caseinate and lecithin had a significant role in decreasing the release of drug during the first 2 min and so in taste-masking. Higher content in lecithin results in higher taste-masking efficiency. The association of sodium caseinate and lecithin seems to be p...Continue Reading

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Citations

Jun 12, 2013·International Journal of Pharmaceutics·Thanh Huong Hoang ThiMarie-Pierre Flament
Sep 11, 2013·International Journal of Pharmaceutics·Thanh Huong Hoang ThiMarie-Pierre Flament
Jun 7, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vandana KharbSuresh Purohit
Sep 11, 2014·Pharmaceutical Research·John N Coupland, John E Hayes
Feb 11, 2014·International Journal of Pharmaceutics·Miriam PeinFlorian E Kiene
Nov 5, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sally GittingsPavel Gershkovich
Oct 3, 2018·Chemical & Pharmaceutical Bulletin·Tsuyoshi KatayamaNoriyuki Namiki
Jul 3, 2019·Therapeutic Delivery·Bartholomew Yir-ErongJoshua S Boateng
Mar 31, 2015·Journal of Materials Science. Materials in Medicine·Junjie YuanYouzhuan Xie
Dec 23, 2020·Chemistry and Physics of Lipids·Surojit BanerjeeVikas Anand Saharan
Feb 2, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Joseph AliPavel Gershkovich
Dec 5, 2020·Pharmaceutical Development and Technology·Marina Delanni Vitória GuedesIrene Clemes Kulkamp Guerreiro
Jun 12, 2017·ACS Biomaterials Science & Engineering·Efrat KorinSmadar Cohen

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