Jun 1, 2007

Development and expansion of high-quality control region databases to improve forensic mtDNA evidence interpretation

Forensic Science International. Genetics
Jodi IrwinThomas J Parsons

Abstract

In an effort to increase the quantity, breadth and availability of mtDNA databases suitable for forensic comparisons, we have developed a high-throughput process to generate approximately 5000 control region sequences per year from regional US populations, global populations from which the current US population is derived and global populations currently under-represented in available forensic databases. The system utilizes robotic instrumentation for all laboratory steps from pre-extraction through sequence detection, and a rigorous eight-step, multi-laboratory data review process with entirely electronic data transfer. Over the past 3 years, nearly 10,000 control region sequences have been generated using this approach. These data are being made publicly available and should further address the need for consistent, high-quality mtDNA databases for forensic testing.

  • References5
  • Citations24

References

  • References5
  • Citations24

Citations

Mentioned in this Paper

DNA, Mitochondrial
Buccal Surface
Genetics, Population
Gene Amplification Technique
Cell Differentiation Process
Sequencing
Telerobotics
Oligonucleotide Primers
Forensic Genetics
Gene Amplification Abnormality

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