Development and External Validation of a Nomogram to Predict Recurrence-Free Survival After R0 Resection for Stage II/III Gastric Cancer: An International Multicenter Study

Frontiers in Oncology
Jun LuChang-Ming Huang

Abstract

Background: The benefit of adjuvant chemotherapy varies widely among patients with stage II/III gastric cancer (GC), and tools predicting outcomes for this patient subset are lacking. We aimed to develop and validate a nomogram to predict recurrence-free survival (RFS) and the benefits of adjuvant chemotherapy after radical resection in patients with stage II/III GC. Methods: Data on patients with stage II/III GC who underwent R0 resection from January 2010 to August 2014 at Fujian Medical University Union Hospital (FMUUH) (n = 1,240; training cohort) were analyzed by Cox regression to identify independent prognostic factors for RFS. A nomogram including these factors was internally and externally validated in FMUUH (n = 306) and a US cohort (n = 111), respectively. Results: The multivariable analysis identified age, differentiation, tumor size, number of examined lymph nodes, pT stage, pN stage, and adjuvant chemotherapy as associated with RFS. A nomogram including the above 7 factors was significantly more accurate in predicting RFS compared with the 8th AJCC-TNM staging system for patients in the training cohort. The risk of peritoneal metastasis was higher and survival after recurrence was significantly worse among patients...Continue Reading

References

Nov 6, 2007·The New England Journal of Medicine·Shinichi SakuramotoUNKNOWN ACTS-GC Group
May 13, 2009·Annals of Surgical Oncology·Ji Fu LaiSung Hoon Noh
May 6, 2010·JAMA : the Journal of the American Medical Association·Xavier PaolettiMarc Buyse
Nov 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christoph SchuhmacherPeter M Schlag
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dong-Seok HanHan-Kwang Yang
Jan 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David M HymanAlexia Iasonos
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S HirabayashiK Akazawa
Jun 11, 2014·Alimentary Pharmacology & Therapeutics·K M Fock
Jun 28, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Oct 25, 2016·International Journal of Surgery·Yusuke MuneokaToshifumi Wakai
Dec 22, 2016·Annals of Surgery·Yuming JiangXiaolong Qi
Mar 1, 2017·The British Journal of Surgery·J S ChangW S Koom
Nov 1, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jun LuPing Li
Feb 11, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Bin-Bin XuPing Li
Aug 8, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M Yu ReutovichO G Sukonko
Oct 1, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Sang-Ho JeongSoon-Chan Hong

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS
R
R package “
DynNom

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