Sep 21, 2004

Development and field validation of a biotic ligand model predicting chronic copper toxicity to Daphnia magna

Environmental Toxicology and Chemistry
Karel A C De Schamphelaere, Colin R Janssen


In this study, we developed a toxicity model predicting the long-term effects of copper on the reproduction of the cladoceran Daphnia magna that is based on previously reported toxicity tests in 35 exposure media with different water chemistries. First, it was demonstrated that the acute copper biotic ligand model (BLM) for D. magna could not serve as a reliable basis for predicting chronic copper toxicity. Consequently, BLM constants for chronic exposures were derived by multiple regression analysis of 21-d median effective concentrations (EC50s; expressed as Cu2+ activity) versus physicochemistry from a large toxicity dataset and the results of an additional experiment in which the individual effect of sodium on copper toxicity was investigated. The effect of sodium on chronic toxicity (log K NaBL = 2.91) seemed to be similar to its effect on acute toxicity (log K NaBL = 3.19). However, in contrast to the acute BLM, no significant calcium, magnesium, or combined competition effect was observed, and an increase in proton competition and bioavailability of CuOH+ and CuCO3 complexes was noted. Some indirect evidence was also found for some limited toxicity of complexes of copper with two of three tested types of dissolved organi...Continue Reading

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Mentioned in this Paper

Daphnia magna
Calcium [EPC]
Magnesium Measurement
Complex (molecular entity)
Toxicity Tests
Water Pollutants
Drug-Induced Liver Injury
Dobsonia magna

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