Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound healing application

Journal of Ethnopharmacology
Chai-Yee ChinShiow-Fern Ng

Abstract

M.oleifera is a medicinal plant traditionally used for skin sores, sore throat and eye infections. Recently, the wound healing property of the leaves of M. oleifera was has been well demonstrated experimentally in both in vivo and in vitro models. However, there is a lack of research which focuses on formulating M.oleifera into a functional wound dressing. In this study, the M.oleifera leaf standardized aqueous extract with highest potency in vitro migration was formulated into a film for wound healing application. Firstly, M. oleifera leaf were extracted in various solvents (aqueous, 50%, 70% and 100% ethanolic extracts) and standardized by reference standards using UHPLC technique. The extracts were then tested for cell migration and proliferation using HDF and HEK cell lines. M. oleifera leaf aqueous extract was then incorporated into alginate-pectin (SA-PC) based film dressing. The film dressings were characterized for the physicochemical properties and the bioactives release from the M. oleifera leaf extract loaded film dressing was also investigated using Franz diffusion cells. All extracts were found to contain vicenin-2, chlorogenic acid, gallic acid, quercetin, kaempferol, rosmarinic acid and rutin. Among all M. oleife...Continue Reading

Citations

Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Chen ZhangJinming Zhang
Dec 13, 2019·BMC Complementary and Alternative Medicine·Nur Zahirah Abd RaniKhairana Husain
May 31, 2020·Pharmaceutics·Joquebede Rodrigues PereiraÁdley Antonini Neves de Lima
Dec 17, 2018·Carbohydrate Polymers·Itzel Rubio-ElizaldeAna B Castro-Ceseña
Aug 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omid YazarluMaede Hasanpour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Asian Pacific Journal of Tropical Medicine
Jackson Rafael Oliveira PeixotoRegine Helena Silva dos Fernandes Vieira
Asian Pacific Journal of Tropical Medicine
Dolly JaiswalGeeta Watal
© 2022 Meta ULC. All rights reserved