Development and Impact of De Novo Anti-HLA Antibodies in Pediatric Heart Transplant Recipients

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
C K ChenAnne I Dipchand

Abstract

There is increasing evidence that de novo anti-HLA antibodies, more specifically de novo donor-specific antibodies (DSA) following solid organ transplantation may be associated with negative outcomes including rejection in the first year and graft loss. Limited data are available in pediatric heart transplant recipients. We sought to prospectively determine the incidence, class and early impact of de novo anti-HLA antibodies in a cohort of pediatric heart transplant recipients. Serial panel reactive antibody testing posttransplant was performed in 25 patients (14 males) transplanted between January 2008 and June 2010. Five patients were sensitized pretransplant; all patients had negative direct crossmatch. Seventy-two percent developed de novo anti-HLA antibodies at a median of 2.6 weeks (IQR 1.2 weeks to 6.2 months) posttransplant; 67% of these were DSA. The majority of recipients in our cohort developed de novo anti-HLA antibodies within the first year posttransplant, with two-thirds being donor-specific. Acute cellular rejection, though frequent, was not different in patients with antibody development regardless of class or specificity, and there was no antibody-mediated rejection, graft loss or early cardiac allograft vascu...Continue Reading

References

Mar 24, 2000·Pediatric Transplantation·M P EmondsR Van Damme-Lombaerts
Jun 8, 2004·Immunologic Research·Robert A BrayHoward M Gebel
Jun 7, 2005·Human Immunology·Sylvie Di FilippoAdriana Zeevi
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Steve XydasJacqueline M Lamour
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan StewartMargaret E Billingham
Jun 27, 2009·Human Immunology·Eric K HoDonna Mancini
Jul 18, 2009·Current Opinion in Organ Transplantation·Robert A Bray, Howard M Gebel
Jul 14, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraPatricia A Uber
Jan 12, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J D SmithM L Rose
Apr 1, 2011·Pediatric Transplantation·Eric K HoNicole Suciu-Foca
Apr 28, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P ArchdeaconR Albrecht
Mar 2, 2013·Journal of the American Society of Nephrology : JASN·Abanti ChaudhuriMinnie M Sarwal
May 23, 2013·Current Opinion in Organ Transplantation·Chris Wiebe, Peter Nickerson
Aug 5, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H M Gebel, R A Bray

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Citations

Nov 2, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adam L WareMelanie D Everitt
Oct 1, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andrew TranBibhuti B Das
Feb 16, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Warren A ZuckermanSteven A Webber
Feb 15, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A I DipchandUNKNOWN CTOTC-04 Investigators
Feb 18, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Mandy LangstraatLuciano Potena
Apr 23, 2019·Current Opinion in Organ Transplantation·Markus J Barten, Andreas Zuckermann
Apr 7, 2020·The Journal of Clinical Investigation·Sam Kant, Daniel C Brennan
Feb 14, 2017·Frontiers in Immunology·Massimo MangiolaAdriana Zeevi
May 16, 2019·Current Opinion in Organ Transplantation·Markus J Barten, Andreas Zuckermann

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