Development and implementation of an antimicrobial lock therapy guideline in a pediatric hospital

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Tracy N ZemblesAnna R Huppler

Abstract

The development and implementation of an antimicrobial lock therapy guideline at a large pediatric hospital are described. Central venous access devices (CVADs) are essential in the medical management of patients requiring long-term total parenteral nutrition, chemotherapy, or hemodialysis. However, the use of a CVAD carries a significant risk of the development of central line-associated bloodstream infection (CLABSI). Antimicrobial lock therapy is indicated for patients with CLABSIs who have no signs of exit site or tunnel infection and for whom catheter salvage is a goal. An antimicrobial lock therapy guideline was developed and implemented at a large pediatric hospital by an interprofessional team consisting of providers specializing in CVAD care. Development and implementation of the guideline included a needs assessment, a literature review, determination of patient selection criteria, addition of compounding formulations, development of administration techniques, and education. In all 10 instances of lock therapy in the 18 months after guideline implementation, the criteria for use were met; in 60% of those instances, patients received care from an infectious diseases physician. Each of the available lock solutions was u...Continue Reading

References

Dec 3, 2004·The Journal of Antimicrobial Chemotherapy·Bart J RijndersWilly E Peetermans
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelis J van RoodenMenno V Huisman
Jul 26, 2005·Infection and Immunity·Robert M Q ShanksGeorge A O'Toole
Apr 7, 2006·The Journal of Antimicrobial Chemotherapy·Nuria Fernandez-HidalgoAlbert Pahissa
Aug 11, 2006·The Journal of Antimicrobial Chemotherapy·J FortúnS Moreno
Oct 5, 2006·Archives of Pediatrics & Adolescent Medicine·Wes OnlandWing-Yen Wong
Feb 6, 2009·The Annals of Pharmacotherapy·P Brandon BookstaverRobert J Sherertz
Jun 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leonard A MermelDavid K Warren
Apr 19, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kevin M Valentine
Sep 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gisela FunallerasAlbert Pahissa
Oct 10, 2012·Pediatrics·Matthew W RallsDaniel H Teitelbaum
Oct 17, 2012·Antimicrobial Agents and Chemotherapy·Brian M PetersMairi C Noverr
Jul 17, 2013·The Pediatric Infectious Disease Journal·Joshua WolfPatricia M Flynn
Dec 4, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·P Brandon BookstaverRobert J Sherertz
Dec 10, 2013·The Lancet Infectious Diseases·David LebeauxChristophe Beloin
Mar 7, 2014·Pediatrics and Neonatology·Chan-Fai Chan, Tzee-Chung Wu
Jun 4, 2014·The Journal of Antimicrobial Chemotherapy·Leonard A Mermel, Neha Alang

❮ Previous
Next ❯

Citations

Oct 17, 2018·Journal of Medical Microbiology·Meredith SchroederBirgit M Prüß
Feb 16, 2020·Methods and Protocols·Aniello AlfieriMarco Fiore
May 25, 2021·ACS Applied Materials & Interfaces·Rajnish KumarElizabeth J Brisbois

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.