Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
A Işılay ÖzdoğanSevda Senel

Abstract

In recent years, statin group drugs have been widely investigated in treatment of periodontal diseases due to their anti-inflammatory effect. The efficacy of statins can be enhanced by local administration into the periodontal pocket by appropriate delivery systems. The aim of our study was to develop a bioadhesive delivery system for local delivery of atorvastatin in treatment of periodontal disease. For this purpose, gel formulations were prepared using different types of chitosan (base and water soluble) and viscosity, bioadhesivity and syringeability of the gels as well as in vitro drug release properties were investigated vitro. Furthermore, anti-inflammatory effect of the formulations was studied in vitro using tumor necrosis factor (TNF)-alfa induced human gingival fibroblast (hGF) cells. Release of proinflammatory (IL-1β, IL-6, IL-8) and anti-inflammatory (TGF-β1, TGF-β2, TGF-β3, IL-10) cytokines were measured after incubating the hGF cells with the formulations. The viscosity of the formulations was found to be suitable for a local application into periodontal pocket. In presence of drug, bioadhesive property of the formulations was found to increase, and bioadhesion force was within the range, which would retain the d...Continue Reading

Citations

Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alicia AguilarGuoqiang Hua
Jul 1, 2020·International Journal of Biological Macromolecules·Elaheh FakhriHossein Samadi Kafil
Mar 27, 2021·Drug Delivery and Translational Research·Sevda ŞenelGülçin Akca
Apr 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying WeiXing Tang
Jun 13, 2020·International Journal of Pharmaceutics·Catherine PetitOlivier Huck
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicolae BaranovDaniela Luminita Ichim
Jul 25, 2021·Materials·Dorota KidaBożena Karolewicz

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