Abstract
In antiphospholipid syndrome (APS), certain principal manifestations are associated with a worse prognosis and organ damage. The objective of this paper is to describe the development and initial content, criterion and construct validity of a disease-specific cumulative damage index in patients with thrombotic APS (DIAPS). Through expert panel agreement, 47 items were considered to reflect damage in APS. This preliminary version of the DIAPS was submitted to four local and international clinical and research experts in APS who ranked each item according to severity. A Delphi exercise resulted in a final 37 item instrument. In the second phase, a cross-sectional study was conducted applying the DIAPS in patients included in a multicenter electronic registry of patients with APS. Quality of life related to health status was evaluated with the EuroQol for construct validation. An α Cronbach and correlation with the EuroQol scale were calculated with SPSS 20.0 (p < 0.05). We evaluated the DIAPS in 156 patients, 77% female, with a mean age at diagnosis 34.7 ± 5.5 years. A total of 69% had primary APS. Common comorbidities included obesity, depression and dyslipidemia. The most frequent manifestations resulting in sequelae were deep ...Continue Reading
References
Apr 1, 1994·Arthritis and Rheumatism·J F FriesC Bombardier
Mar 1, 1996·Arthritis and Rheumatism·D GladmanA Zoma
Nov 5, 1990·Health Policy·UNKNOWN EuroQol Group
Nov 24, 1999·Lupus·D D Gladman, M B Urowitz
Aug 5, 2000·QJM : Monthly Journal of the Association of Physicians·M G TektonidouH M Moutsopoulos
Sep 2, 2000·Journal of Autoimmunity·D Alarcón-SegoviaA R Villa
Jun 14, 2001·Sexually Transmitted Diseases·D B ReinK L Irwin
Sep 6, 2001·Rheumatic Diseases Clinics of North America·M C Amigo
Apr 16, 2002·Arthritis and Rheumatism·Ricard CerveraUNKNOWN Euro-Phospholipid Project Group
Jan 14, 2004·Archives of Internal Medicine·Guillermo Ruiz-IrastorzaCiriaco Aguirre
Jan 20, 2006·Journal of Thrombosis and Haemostasis : JTH·S MiyakisS A Krilis
Jan 17, 2012·The Journal of Rheumatology·Eleftheria P GrikaPanayiotis G Vlachoyiannopoulos
May 29, 2012·Lupus·R Cervera
Jan 3, 2013·The Journal of Rheumatology·Medha Barbhaiya, Doruk Erkan
Feb 13, 2013·The Journal of Rheumatology·Panayiotis G Vlachoyiannopoulos
Jan 30, 2014·Lupus·J SwadzbaJ Musial
Citations
Jan 16, 2016·Current Rheumatology Reports·P AlbaM C Amigo
Jul 16, 2014·Reumatología clinica·Isabel CastrejónLoreto Carmona
Mar 7, 2017·International Journal of Rheumatic Diseases·Gabriela Hernández-MolinaAntonio R Cabral
Dec 20, 2015·Lupus·L M Amezcua-Guerra
Mar 10, 2016·Lupus·M HammadS Fathi
Oct 5, 2018·Annals of the Rheumatic Diseases·Imad UthmanMunther Khamashta
Aug 5, 2017·Nature Reviews. Rheumatology·Savino SciasciaMunther Khamashta
Dec 4, 2019·Lupus·M-C Amigo, P Alba
Jan 29, 2020·Lupus·A Kuhl TorricelliD Andrade
May 3, 2020·Rheumatology·Pedro GasparDavid A Isenberg
May 15, 2020·Current Rheumatology Reports·Marie DesnoyersStéphane Zuily
Nov 13, 2020·Lupus·Gabriela MedinaLuis J Jara
Jun 30, 2019·Journal of Autoimmunity·Marc Pineton de ChambrunUNKNOWN SAPHIR study group
Apr 24, 2021·Rheumatology International·Y Juárez-VicuñaF Sánchez-Muñoz
May 2, 2021·Current Rheumatology Reports·Doruk ErkanUNKNOWN APS ACTION Executive Committee
Jun 11, 2021·Advances in Rheumatology·Fatema T ElgengehyTamer A Gheita
Aug 1, 2021·European Journal of Internal Medicine·Massimo RadinSavino Sciascia
Nov 30, 2019·Chest·Marc Pineton de ChambrunZahir Amoura