Development and leading-edge application of innovative photoaffinity labeling

Chemical & Pharmaceutical Bulletin
Yasumaru Hatanaka

Abstract

Photoaffinity labeling has become increasingly important with the development of powerful specific probes that are synthesized by installing a photo-activatable functional group (photophore) on the framework of biological ligands. The present review summarizes the development of diazirine-based photoaffinity labeling by focusing on its application to the structural elucidation of ligand-accepting sites within proteins.

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Mar 29, 2016·Bioconjugate Chemistry·Yoshimasa KawaguchiShiroh Futaki
Aug 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei WangMakoto Hashimoto
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Apr 24, 2018·Journal of Medicinal Chemistry·James R Hill, Avril A B Robertson

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