PMID: 8956344Nov 1, 1996Paper

Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases

Pharmaceutical Research
D S JonesW A Coulter

Abstract

This study examined the mechanical characteristics and release of tetracycline from bioadhesive, semi-solid systems which were designed for the treatment of periodontal diseases. Tetracycline release into phosphate buffered saline (pH 6.8, 0.03 M) was examined using a Caleva 7ST dissolution apparatus at 37 degrees C. The mechanical properties of each formulation (hardness, compressibility, adhesiveness, elasticity and cohesiveness) were determined using texture profile analysis. Syringeability was measured using the texture analyser in compression mode as the work of syringeability i.e. the force required to express the product from a periodontal syringe over a defined distance. Tetracycline release from all formulations was zero-order for 24-54 h and ranged from 1.59 +/- 0.20 to 15.80 +/- 0.50 mg h-1. Increased concentrations of hydroxyethylcellulose (HEC) decreased the rate of release of tetracycline, due to the concomitant increase in product viscosity and the subsequent decreased rate of penetration of dissolution fluid into the formulation. Conversely, an increased polyvinylpyrrolidone (PVP) concentration increased tetracycline release rates, due to an increased formulation porosity following dissolution of this polymer. I...Continue Reading

Citations

Apr 20, 2000·Journal of Clinical Pharmacy and Therapeutics·S P VyasV Mishra
Sep 21, 2007·Drug Development and Industrial Pharmacy·Sameh M Abdel-HamidHadir F El-Dessouky
Jun 3, 2011·Drug Development and Industrial Pharmacy·Franciele Viana FabriMarcos Luciano Bruschi
Oct 24, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jean-Michel CoutuSophie Lerouge
May 15, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aslı Sedef CanYıldız Özsoy
Aug 23, 2008·Drug Development and Industrial Pharmacy·G S AsaneY Madhusudan Rao
Mar 9, 2010·Journal of Biomaterials Applications·Sanju DhawanDeepak N Kapoor
Apr 20, 2018·Drug Development and Industrial Pharmacy·Rania HamedOla Tarawneh
Sep 14, 2018·AAPS PharmSciTech·Lucas de Alcântara Sica de ToledoMarcos Luciano Bruschi
Jan 7, 2020·Pharmaceutical Development and Technology·Fernanda Belincanta Borghi-PangoniMarcos Luciano Bruschi
Apr 16, 2005·Drug Development and Industrial Pharmacy·Marcos Luciano Bruschi, Osvaldo de Freitas
Feb 3, 2007·Journal of Materials Science. Materials in Medicine·Ling-Chong WangQuan-Chen Xu
Sep 12, 2008·Drug Development and Industrial Pharmacy·Heba A GadSeham S Abd el-Hady
Aug 19, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Young-Seok NohSang-Hoon Rhee
Aug 30, 2014·Pharmaceutical Research·Thiago CaonJoseph A Nicolazzo
Jan 21, 2014·Pharmaceutical Development and Technology·Abeer Ahmed KassemElsayed Aboulmagd
Dec 12, 2012·Drug Development and Industrial Pharmacy·Flávia Chiva CarvalhoMarlus Chorilli
Jul 10, 2008·Drug Development and Industrial Pharmacy·Mai MansourSeham S Abd Elhady
Mar 17, 2010·Pharmaceutical Development and Technology·Sushila BhattaraiRaid G Alany
Aug 13, 2020·Drug Delivery and Translational Research·Ashlee C GreeneSteven R Little
Aug 25, 2015·Journal of Biomaterials Science. Polymer Edition·Fatmanur Tuğcu-DemirözAykut Özkul
Mar 9, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Évelin L de OliveiraWilker Caetano
Oct 2, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·T MiyazakiS Okada
Feb 19, 2000·The Journal of the American Dental Association·M PadillaR L Merrill
Feb 9, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Viralkumar F PatelMarc B Brown

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