Development and optimisation of an on-line solid phase extraction coupled to ultra-high-performance liquid chromatography-tandem mass spectrometry methodology for the simultaneous determination of endocrine disrupting compounds in wastewater samples

Journal of Chromatography. a
T Vega-MoralesJosé Juan Santana-Rodríguez

Abstract

A process using a fully automated on-line solid-phase extraction system combined with ultra-high-performance liquid chromatography and tandem mass spectrometry detection (SPE-UHPLC-MS/MS) has been developed and applied to the determination of 27 endocrine disrupting compounds (EDCs) in sewage samples. This technology allows separation and detection of all substances in a single chromatographic run that requires less than 4 min. In order to obtain a more sensitive method for the quantification of these compounds in sewage samples, an on-line solid-phase extraction step with Oasis HLB columns was performed prior to chromatographic determination. The complete analysis of each sample by this process requires only 9 min, provides satisfactory recoveries (72-110%) and limits of detection on the order of a few nanograms per liter (0.3-2.1 ng L(-1)), demonstrating their potential for analyses of environmental samples. Thus, this methodology has been applied to samples collected from two wastewater treatment plants (WWTPs) located in Las Palmas de Gran Canaria (Canary Islands, Spain). One of these plants utilised conventional activated sludge treatment (CAS), while the other employed biomembrane reactor treatment (MBR).

References

Sep 24, 2004·Rapid Communications in Mass Spectrometry : RCM·Robert PlumbAndrew Wright
Jan 5, 2008·Environmental Health Perspectives·Andreas Kortenkamp

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Citations

Apr 29, 2014·Analytical and Bioanalytical Chemistry·Maria Concetta BruzzonitiMassimo Del Bubba
Oct 10, 2014·Journal of Separation Science·Carme Valls-CantenysVictòria Salvadó
May 27, 2014·The Science of the Total Environment·Germana P PessoaAndré B dos Santos
Nov 14, 2014·Critical Reviews in Analytical Chemistry·Baljinder SinghAshok Kumar Malik
Nov 14, 2014·Critical Reviews in Analytical Chemistry·Cláudia RibeiroMaria Elizabeth Tiritan
Dec 16, 2017·Environmental Monitoring and Assessment·K K NejumalC T Aravindakumar

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