Development and optimization of solid self-nanoemulsifying drug delivery system (S-SNEDDS) using Scheffe's design for improvement of oral bioavailability of nelfinavir mesylate

Drug Delivery and Translational Research
Archita PatelAnita Lalwani

Abstract

The present research was aimed at development and evaluation of self-nanoemulsifying drug delivery system (SNEDDS) for improving bioavailability of nelfinavir mesylate (NFV), a protease inhibitor exhibiting pH dependent solubility and variable oral bioavailability. Maisine 35-1, Cremophor RH-40, and Labrasol were identified as oil, surfactant, and co-surfactant that had best solubility for NFV. Scheffe's mixture design was used to optimize the amount of components in liquid self-nanoemulsifying drug delivery system (L-SNEDDS) by taking their amounts as independent variable, whereas globule size, drug loading, and percent transmittance were taken as dependent variable. Optimized NFV-L-SNEDDS was then adsorbed on Neusilin US2 to form solid self-nanoemulsifying drug delivery system (S-SNEDDS). NFV loaded L-SNEDDS and S-SNEDDS were characterized for various physicochemical properties, and solid-state properties were determined through differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy studies. In vitro dissolution using simulated gastric fluid and simulated intestinal fluid, ex vivo drug release study, and in vivo study were performed for pure NFV and NFV-S-SNEDDS. NFV-S-SNEDDS showed more than 9...Continue Reading

References

Jan 1, 1996·Pharmaceutical Biotechnology·P L Smith
Jun 6, 2000·Advanced Drug Delivery Reviews·G C Williams, P J Sinko
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T Gershanik, S Benita
Sep 5, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bhagwant D RegeJames E Polli
Oct 18, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·A JanolyG Aulagner
May 7, 2003·Clinical Pharmacology and Therapeutics·Cristoph WandelC Michael Stein
May 26, 2004·International Journal of Pharmaceutics·Gilles CornaireGeorges Houin
Mar 24, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xianyi ShaXiaoling Fang
Apr 19, 2005·Molecular Pharmaceutics·Nehal A KasimGordon L Amidon
Mar 21, 2006·Journal of Pharmaceutical and Biomedical Analysis·Qiufang JingZhian Hou
Jul 10, 2007·Advanced Drug Delivery Reviews·David J Hauss
Aug 11, 2007·Micron : the International Research and Review Journal for Microscopy·Jean-Christophe ColasHarjinder Singh
May 1, 2008·AAPS PharmSciTech·Amit A Kale, Vandana B Patravale
Jul 7, 2009·The American Journal of Cardiology·Evan A SteinJohn J P Kastelein
Jul 29, 2009·International Journal of Pharmaceutics·Yosra S R ElnaggarOssama Y Abdallah
Feb 26, 2010·AAPS PharmSciTech·Adhvait R DixitSamir G Patel
Apr 20, 2010·Journal of Pharmaceutical and Biomedical Analysis·Parul SinghA K Bakhshi
Jul 28, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Saipin SetthacheewakulRuedeekorn Wiwattanapatapee
Nov 27, 2010·Pharmaceutical Development and Technology·Paola MuraNatascia Mennini
May 10, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Srinivasan ShanmugamBong Kyu Yoo
Nov 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jun Hyeok KangHan-Gon Choi

❮ Previous
Next ❯

Citations

Apr 2, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Shailja TripathiSanyog Jain
Feb 11, 2015·Clinical Pharmacokinetics·Kamla Pathak, Smita Raghuvanshi
Feb 1, 2017·Journal of Pharmaceutical Sciences·Ožbej ZupančičAndreas Bernkop-Schnürch
Jan 5, 2020·Drug Delivery and Translational Research·Nihal Farid YounesAmal I A Makhlouf
Aug 5, 2020·Drug Delivery and Translational Research·Malobika Chakravarty, Amisha Vora
Aug 11, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Saurabh ShahSaurabh Srivastava
Oct 9, 2021·BMC Complementary Medicine and Therapies·Mira Nadiah Mohd IzhamNoorjahan Banu Alitheen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.